Impact of Coriandrum sativum seeds extract on albino rats' testicular toxicity caused by carbendazim.

IF 2.2 4区医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2023-12-01 DOI:10.1093/toxres/tfad109

Ehab Tousson, Somaya Y Shalaby, Doaa M El-Gharbawy, Mohamed A Akela, Mohamed Rabea, Eman H Kandil

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Abstract

Background: A broad spectrum carbamate fungicide called carbendazim (Carb) is used to combat a number of different fungal diseases. One of the extensively utilized medicinal plants in oriental countries is Coriandrum sativum.

Aim: In the current study, the impact of C. sativum seeds extract (CSE) on albino rats' testicular toxicity caused by carbendazim was investigated.

Materials and methods: A total of 50 male albino rats were classified into 5 groups [Gp1, Control Gp; Gp2, Coriandrum Gp (CSE); Gp 3, carbendazim Gp (Carb); Gp 4, Co treated CSE with Carb (CSE + Carb); Gp 5, Post treated Carb with CSE (Carb + CSE)].

Results: Carb induced elevation in serum LH. FSH, testicular malondialdehyde (MDA), testicular nitric oxide (NO) markers and testicular injury and it reduced serum testosterone, testicular glutathione (GSH), testicular catalase and PCNA. Treatments of Carb with CSE (CSE + Carb and/or Carb + CSE) improved these parameters and reduced testicular toxicity with best results for Carb + CSE than CSE + Carb.

Conclusions: The above findings revealed that; Carb induced testicular toxicity and it supported the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.

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芫荽籽提取物对多菌灵引起的白化大鼠睾丸毒性的影响

背景：一种名为多菌灵（Carb）的广谱氨基甲酸酯类杀菌剂被用于防治多种真菌疾病。目的：本研究调查了芫荽种子提取物（CSE）对多菌灵引起的白化大鼠睾丸毒性的影响：将 50 只雄性白化大鼠分为 5 组[Gp1，对照组；Gp2，芫荽籽提取物（CSE）；Gp3，多菌灵提取物（Carb）；Gp4，CSE 与 Carb 共同处理组（CSE + Carb）；Gp5，CSE 与 Carb 后处理组（Carb + CSE）]：结果：碳水化合物诱导血清 LH、FSH、睾丸恶液质升高。FSH、睾丸丙二醛（MDA）、睾丸一氧化氮（NO）标记物和睾丸损伤的升高，并降低血清睾酮、睾丸谷胱甘肽（GSH）、睾丸过氧化氢酶和 PCNA。用 CSE 处理 Carb（CSE + Carb 和/或 Carb + CSE）可改善这些参数并降低睾丸毒性，其中 Carb + CSE 的效果最好：上述研究结果表明，Carb 会诱发睾丸毒性，这支持了一种假设，即一种或多种 CSE 成分的抗氧化特性可降低 Carb 的睾丸毒性。

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