The use of CytoSorb in acute oral mercuric chloride poisoning at a potentially lethal dose.

IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL International Journal of Artificial Organs Pub Date : 2024-01-01 Epub Date: 2023-12-23 DOI:10.1177/03913988231215631
Anna Krakowiak, Beata Janasik, Łukasz Sadowski, Katarzyna Szwabe, Tomasz Wiśniewski, Małgorzata Anna Rak, Waldemar Machała
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Abstract

Introduction: The study aims to present a case of acute mercuric chloride poisoning treated successfully with continuous renal replacement therapy using the CytoSorb filter.

Case description: A 21-year-old female patient after a suicide attempt by intentional ingestion of mercuric chloride, was admitted to the hospital with features of multiple organ damage for specific treatment. The performed laboratory tests confirmed high levels of mercury in the blood (1051 μg/L) and urine (22,960 μg/L). Due to acute renal failure, continuous renal replacement therapy (CRRT) CVVHD Ci-Ca was initiated; the procedure was then converted to CVVHDF Ci-Ca with ultrafiltration to optimise therapy, and CytoSorb was added to the artificial kidney system on day 3. Specific antidote therapy (DMPS) was administered concurrently. The ongoing treatment resulted in a reduction in subjective complaints, a decrease in blood mercury levels to 580 μg/L, and an improvement in parenchymal organ function.

Conclusion: In the event of poisoning with inorganic mercury compounds (mercuric chloride), continuous renal replacement therapy using the CytoSorb filter as an extracorporeal blood purification method may be considered.

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在可能致死剂量的急性口服氯化汞中毒中使用 CytoSorb。
简介本研究旨在介绍一例使用 CytoSorb 过滤器进行持续肾脏替代治疗并获得成功的急性氯化汞中毒病例:一名 21 岁的女性患者因故意摄入氯化汞自杀未遂,入院接受特殊治疗时出现多器官损伤。实验室检测证实,患者血液(1051 微克/升)和尿液(22960 微克/升)中汞含量较高。由于急性肾功能衰竭,患者开始接受连续肾脏替代疗法(CRRT)CVVHD Ci-Ca;随后转为超滤CVVHDF Ci-Ca,以优化治疗,并在第3天将CytoSorb添加到人工肾脏系统中。同时还进行了特定的解毒治疗(DMPS)。通过持续治疗,主观症状有所减轻,血汞水平降至 580 μg/L,实质器官功能有所改善:结论:在无机汞化合物(氯化汞)中毒的情况下,可以考虑使用 CytoSorb 过滤器作为体外血液净化方法进行持续的肾脏替代治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Artificial Organs
International Journal of Artificial Organs 医学-工程:生物医学
CiteScore
3.40
自引率
5.90%
发文量
92
审稿时长
3 months
期刊介绍: The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.
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