Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-12-27 DOI:10.1007/s10522-023-10082-7
Xiao-Ming Wang, Lu Fan, Chen-Chen Meng, Yun-Jiao Wang, Li-E Deng, Zhuo Yuan, Jun-Ping Zhang, Yan-Yang Li, Shi-Chao Lv
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Abstract

Frailty syndrome denotes a decreased capacity of the body to maintain the homeostasis and stress of the internal environment, which simultaneously increases the risk of adverse health outcomes in older adults, including disability, hospitalization, falls, and death. To promote healthy aging, we should find strategies to cope with frailty. However, the pathogenesis of frailty syndrome is not yet clear. Recent studies have shown that the diversity, composition, and metabolites of gut microbiota significantly changed in older adults with frailty. In addition, several frailty symptoms were alleviated by adjusting gut microbiota with prebiotics, probiotics, and symbiosis. Therefore, we attempt to explore the pathogenesis of frailty syndrome in older people from gut microbiota and summarize the existing interventions for frailty syndrome targeting gut microbiota, with the aim of providing timely and necessary interventions and assistance for older adults with frailty.

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肠道微生物群对老年人虚弱综合征的影响:机制与治疗策略。
虚弱综合征是指机体维持体内平衡和内环境压力的能力下降,这同时增加了老年人出现不良健康后果的风险,包括残疾、住院、跌倒和死亡。为了促进健康老龄化,我们应该找到应对虚弱的策略。然而,虚弱综合征的发病机理尚不清楚。最近的研究表明,患有虚弱症的老年人肠道微生物群的多样性、组成和代谢物发生了显著变化。此外,通过使用益生菌、益生菌和共生菌调整肠道微生物群,一些虚弱症状得到了缓解。因此,我们试图从肠道微生物区系探讨老年人虚弱综合征的发病机制,并总结现有的针对肠道微生物区系的虚弱综合征干预措施,以期为患有虚弱综合征的老年人提供及时、必要的干预和帮助。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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