Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges.

IF 3.9 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Frontiers of Medicine Pub Date : 2023-12-01 Epub Date: 2023-12-27 DOI:10.1007/s11684-023-1050-6

Zhichen Jiang, Xiaohao Zheng, Min Li, Mingyang Liu

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Abstract

Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challenge owing to scarce treatment alternatives. This review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiology, genomic characterization, risk factors, diagnosis, therapeutic strategies, and treatment resistance mechanisms. We delve into identifying risk factors, including genetic predisposition and environmental exposures, and explore recent research advancements in precursor lesions and molecular subtypes of pancreatic cancer. Additionally, we highlight the development and application of multi-omics approaches in pancreatic cancer research and discuss the latest combinations of pancreatic cancer biomarkers and their efficacy. We also dissect the primary mechanisms underlying treatment resistance in this malignancy, illustrating the latest therapeutic options and advancements in the field. Conclusively, we accentuate the urgent demand for more extensive research to enhance the prognosis for pancreatic cancer patients.

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改善胰腺癌的预后：从流行病学、基因组变化和治疗挑战中获得启示。

胰腺癌因其诊断晚、病情发展凶险而臭名昭著，由于缺乏替代治疗方法，胰腺癌的治疗面临巨大挑战。本综述旨在提供对胰腺癌的整体认识，包括其流行病学、基因组特征、风险因素、诊断、治疗策略和耐药机制。我们深入探讨了包括遗传易感性和环境暴露在内的风险因素，并探讨了胰腺癌前体病变和分子亚型的最新研究进展。此外，我们还重点介绍了多组学方法在胰腺癌研究中的发展和应用，并讨论了胰腺癌生物标记物的最新组合及其功效。我们还剖析了这种恶性肿瘤耐药的主要机制，说明了该领域的最新治疗方案和进展。最后，我们强调迫切需要进行更广泛的研究，以改善胰腺癌患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers of Medicine ONCOLOGYMEDICINE, RESEARCH & EXPERIMENTAL&-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

18.30

自引率

0.00%

发文量

800

期刊介绍： Frontiers of Medicine is an international general medical journal sponsored by the Ministry of Education of China. The journal is jointly published by the Higher Education Press and Springer. Since the first issue of 2010, this journal has been indexed in PubMed/MEDLINE. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine, translational research, healthcare, public health and health policies.