Spotlight on Compounded Bioidentical Hormones.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY Gynecologic and Obstetric Investigation Pub Date : 2024-01-01 Epub Date: 2023-12-27 DOI:10.1159/000535982

Giusi Santangelo, Antonio Simone Lagana, Andrea Giannini, Filippo Murina, Camilla Di Dio, Gianfilippo Ruggiero, Violante Di Donato, Giorgia Perniola, Margherita Fischetti, Assunta Casorelli, Francesco Clemente, Marianna Minnetti, Francesco Lombardo, Pierluigi Benedetti Panici, Ludovico Muzii, Giorgio Bogani

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Abstract

Background: The role of hormonal replacement therapy in menopause is under debate. The premature closure of the Women's Health Initiative (WHI) study in 2002 is still a source of concern among treating physicians.

Objectives: The interest in alternatives to conventional hormone therapy has significantly increased. The adoption of personalized steroid hormone galenic preparations, formulated by compounding pharmacies, has recently spread.

Methods: In June 2023, an extensive literature search was conducted by different authors to identify relevant studies in various databases (MEDLINE, Embase, PubMed, and Cochrane). The studies that met the inclusion and exclusion criteria were further analyzed, and relevant data were extracted and analyzed for each paper. Any discrepancies between the investigators were resolved through a consensus approach.

Outcomes: The primary outcomes observed included the clinical utility of CBHT. This study reviewed the current evidence on the utility of compounded bioidentical hormones, concluding that improving knowledge and awareness of bioidentical hormones is necessary to consider their use in clinical practice.

Conclusion and outlook: These formulations might provide effective options to best tailor therapies to each patient.

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聚焦复方生物相同激素。

背景：激素替代疗法在更年期中的作用一直备受争议。2002 年提前结束的 "妇女健康倡议"（WHI）研究仍然是治疗医生关注的焦点：目的：人们对传统激素疗法替代品的兴趣大大增加。最近，由复合药房配制的个性化类固醇激素 galenic 制剂已被广泛采用：2023 年 6 月，不同作者进行了广泛的文献检索，以确定各种数据库（MEDLINE、Embase、Pubmed 和 Cochrane）中的相关研究。对符合纳入和排除标准的研究进行了进一步分析，并提取和分析了每篇论文的相关数据。研究者之间的任何分歧均通过协商一致的方式解决：观察到的主要结果包括 CBHT 的临床效用。本研究回顾了目前有关复方生物同源激素效用的证据，得出结论认为，要考虑在临床实践中使用复方生物同源激素，就必须提高对其的了解和认识：这些制剂可能会提供有效的选择，为每位患者提供最适合的疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic and Obstetric Investigation 医学-妇产科学

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.