Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2024-02-01 Epub Date: 2023-12-28 DOI:10.1089/jir.2023.0101
Richard Salama-Frisbie, Cinthia A Molina-Flores, Arguiñe I Urraza-Robledo, María E Gutiérrez-Pérez, Alberto A Miranda-Pérez, Alhi A Gutiérrez-Salas, Jorge Haro-Santa Cruz, Francisco C López-Márquez
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Abstract

Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2). COVID-19 can cause a cytokine release syndrome in which cytokines, including interleukin 17 (IL-17), are massively secreted in response to a specific stimulus. This can contribute to mortality and severe forms of COVID-19. The study aimed to determine the association of SARS-CoV2 infection with the IL-17A rs2275913 and IL-17F rs763780 variants, as well as with the associated comorbidities in COVID-19-positive Mexican patients. The study included 178 patients positive to COVID-19 and 177 COVID-19 negative subjects. For genotyping, the samples were amplified with a TaqMan® probe. There was no association between the AA genotype and A allele of IL-17A variant or the IL-17F C allele with the presence of COVID-19. In regard to comorbidities, a statistically significant association was found between IL-17A rs2275913 AA genotype and hypertension, as well as with the presence of obesity (P = 0.003, OR 23, 95% CI: 2.97-178.092 and P = 0.025, OR 28, 95% CI: 1.52-178.029, respectively) in patients with COVID-19. In conclusion, rs2275913 IL-17A polymorphism in COVID-19 patients seems to confer a higher susceptibility to the presence of hypertension and obesity, increasing the risk of premature cardiovascular disease in this population. However, more studies should be conducted for a better understanding of their relation.

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IL-17A和IL-17F基因多态性与墨西哥 COVID-19 患者高血压和肥胖症风险增加的关系。
冠状病毒病 2019(COVID-19)是由严重急性呼吸系统综合征冠状病毒-2(SARS-CoV2)引起的。COVID-19 可导致细胞因子释放综合征,即细胞因子(包括白细胞介素 17 (IL-17))在特定刺激下大量分泌。这可能导致死亡和严重的 COVID-19。该研究旨在确定 SARS-CoV2 感染与 IL-17A rs2275913 和 IL-17F rs763780 变体的关系,以及 COVID-19 阳性的墨西哥患者的相关合并症。该研究包括 178 名 COVID-19 阳性患者和 177 名 COVID-19 阴性受试者。在进行基因分型时,使用 TaqMan® 探针对样本进行扩增。IL-17A变体的AA基因型和A等位基因或IL-17F的C等位基因与COVID-19的存在没有关联。在合并症方面,在 COVID-19 患者中,IL-17A rs2275913 AA 基因型与高血压以及肥胖(分别为 P = 0.003,OR 23,95% CI:2.97-178.092 和 P = 0.025,OR 28,95% CI:1.52-178.029)之间存在统计学意义上的显著关联。总之,COVID-19 患者的 rs2275913 IL-17A 多态性似乎更容易导致高血压和肥胖,从而增加该人群过早罹患心血管疾病的风险。然而,要更好地了解它们之间的关系,还需要进行更多的研究。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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