Physical activity, sitting time, and thermal quantitative sensory testing responses in African Americans.

IF 3.4 Q2 NEUROSCIENCES Pain Reports Pub Date : 2023-12-26 eCollection Date: 2023-12-01 DOI:10.1097/PR9.0000000000001118
Felicitas A Huber, Rachel Carpenter, Burel R Goodin, Stephen Bruehl, Cynthia Karlson, Uma Rao, Kerry Kinney, Subodh Nag, Matthew C Morris
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Abstract

Introduction: Prior research suggests that African Americans (AAs) have more frequent, intense, and debilitating pain and functional disability compared with non-Hispanic Whites (NHWs). Potential contributing factors to this disparity are physical activity and sedentary behavior, given that AAs are less physically active, and physical activity is associated with antinociception (whereas sedentary behavior is linked to pronociception). However, impact of these factors on pain processing has largely been unexplored in AAs, especially before chronic pain onset.

Objective: This study examined relationships between physical activity, sedentary behavior (sitting time), and laboratory measures of pain and pain modulation in adult AAs. These included heat pain threshold and tolerance, temporal summation of pain (TSP, a marker of central sensitization), and conditioned pain modulation (CPM, a marker of descending pain inhibition).

Methods: Multiple regressions were conducted to examine the effects of physical activity and sitting time on heat threshold and tolerance. Multilevel models were conducted to assess the relationship between physical activity, sitting time, and temporal summation of pain. Additional multilevel models were conducted to assess the relationship between physical activity, sitting time, and conditioned pain modulation.

Results: Higher level of physical activity, but not sitting time, was associated with reduced TSP slopes. Neither physical activity nor sitting time was associated with CPM slopes. No significant relationships between physical activity or sitting time and heat pain threshold or tolerance were detected.

Conclusions: These findings suggest that physical activity is associated with reduced TSP, an effect which may be driven by reduced spinal hyperexcitability in more active individuals. Thus, structural and individual interventions designed to increase physical activity in healthy, young AAs may be able to promote antinociceptive processes (ie, reduced TSP/reduced pain facilitation) potentially protective against chronic pain.

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非裔美国人的体力活动、久坐时间和热定量感官测试反应。
导言:先前的研究表明,与非西班牙裔白人(NHWs)相比,非裔美国人(AAs)的疼痛和功能性残疾更为频繁、剧烈和虚弱。造成这种差异的潜在因素是体力活动和久坐行为,因为非裔美国人的体力活动较少,而体力活动与抗痛觉相关(久坐行为则与代痛觉相关)。然而,这些因素对AA族疼痛处理的影响在很大程度上尚未被研究,尤其是在慢性疼痛发作之前:本研究调查了成年机甲病患者的体力活动、久坐行为(久坐时间)与疼痛和疼痛调节的实验室测量之间的关系。这些指标包括热痛阈值和耐受性、疼痛的时间累加(TSP,中枢敏化的标志)和条件性疼痛调节(CPM,降序疼痛抑制的标志):方法:采用多元回归法研究体力活动和久坐时间对热阈值和耐受性的影响。采用多层次模型来评估体力活动、坐姿时间和疼痛时间总和之间的关系。另外还建立了多层次模型,以评估体力活动、坐着时间和条件性疼痛调节之间的关系:结果:较高水平的体力活动(而非久坐时间)与 TSP 斜率的降低有关。体力活动和久坐时间都与 CPM 斜率无关。没有发现体力活动或久坐时间与热痛阈值或耐受性之间有明显关系:这些研究结果表明,体力活动与热痛阈值降低有关,这种效应可能是由于体力活动较多的人脊柱过度兴奋性降低所致。因此,旨在增加健康、年轻的机能障碍者体育锻炼的结构性和个体干预措施可能会促进抗痛觉过程(即减少 TSP/减少疼痛促进),从而对慢性疼痛起到潜在的保护作用。
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来源期刊
Pain Reports
Pain Reports Medicine-Anesthesiology and Pain Medicine
CiteScore
7.50
自引率
2.10%
发文量
93
审稿时长
8 weeks
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