1,3,4-Thiadiazole: A Versatile Scaffold for Drug Discovery

IF 0.7 4区 化学 Q4 CHEMISTRY, ORGANIC Letters in Organic Chemistry Pub Date : 2023-12-27 DOI:10.2174/0115701786274678231124101033
Ravi K. Mittal, Raghav Mishra, Vikram Sharma, Isha Mishra
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Abstract

:: 1,3,4-Thiadiazole has garnered considerable attention in the scientific community due to its captivating molecular structure and ability to serve as a foundation for creating novel pharmaceutical compounds. Numerous medications feature the 1,3,4-thiadiazole ring in their chemical structure, highlighting its relevance and efficacy in pharmaceutical research and development. The key objective of this comprehensive review is to provide an understandable overview of the chemistry and diverse pharmacological activities associated with 1,3,4-thiadiazole compounds. The manuscript was compiled by conducting a thorough literature review, which included an in-depth analysis of globally esteemed scientific research databases. The remarkable chemical characteristics and diverse pharmacological impacts of 1,3,4-Thiadiazole highlight its significant potential as a structural scaffold for the development of novel therapeutic substances. Based on the information available on synthetic molecules that incorporate the 1,3,4-thiadiazole framework and their wide range of uses, it is reasonable to expect significant advancements in the near future and the possibility of employing these compounds in different domains.
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1,3,4-噻二唑:药物发现的多功能支架
1,3,4-噻二唑因其迷人的分子结构和作为创造新型药物化合物基础的能力而在科学界引起了广泛关注。许多药物的化学结构中都含有 1,3,4-噻二唑环,凸显了其在药物研发中的相关性和有效性。这篇综合综述的主要目的是对 1,3,4-噻二唑化合物的化学性质和多种药理活性进行通俗易懂的概述。手稿是通过全面的文献综述编写而成,其中包括对全球知名科研数据库的深入分析。1,3,4-噻二唑具有显著的化学特性和多种药理作用,这凸显了它作为一种结构支架开发新型治疗物质的巨大潜力。根据有关包含 1,3,4-噻二唑框架的合成分子及其广泛用途的现有信息,我们有理由期待这些化合物在不久的将来取得重大进展,并有可能应用于不同领域。
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来源期刊
Letters in Organic Chemistry
Letters in Organic Chemistry 化学-有机化学
CiteScore
1.30
自引率
12.50%
发文量
135
审稿时长
7 months
期刊介绍: Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.
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