Smoking Disturbs the Beneficial Effects of Continuous Positive Airway Pressure Therapy on Leptin Level in Obstructive Sleep Apnea.

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Journal of Obesity & Metabolic Syndrome Pub Date : 2023-12-30 DOI:10.7570/jomes23030

Merve Aktan Suzgun, Vasfiye Kabeloglu, Gülcin Benbir Senel, Derya Karadeniz

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Abstract

Background: This study aimed to determine how smoking alters the effect of positive airway pressure (PAP) therapy on metabolic syndrome in obstructive sleep apnea (OSA).

Methods: In this clinical trial, morphometric measures, metabolic syndrome parameters, and apnea-hypopnea index (AHI) in OSA patients were recorded and compared between active smokers and non-smokers. The mean change in metabolic syndrome parameters measured before and after 3 months of PAP therapy was determined. The study included 72 males and 43 females.

Results: Morphometric values and mean AHI did not differ between active smokers and non-smokers. When the percentage of unchanged, increased, or decreased metabolic parameters measured before and after treatment was analyzed, leptin level tended to increase in active smokers with OSA after PAP therapy compared with non-smokers (P=0.034, adjusted for confounders).

Conclusion: Serum leptin level was stable or decreased in non-smokers, while 40% of active smokers had increased leptin level. Therefore, smoking plays a predisposing role in leptin resistance despite PAP therapy in OSA patients.

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吸烟会干扰持续气道正压疗法对阻塞性睡眠呼吸暂停患者瘦素水平的有益影响

背景：本研究旨在确定吸烟如何改变气道正压疗法对阻塞性睡眠呼吸暂停（OSA）患者代谢综合征的影响：本研究旨在确定吸烟如何改变气道正压疗法对阻塞性睡眠呼吸暂停（OSA）患者代谢综合征的影响：在这项临床试验中，记录了 OSA 患者的形态测量、代谢综合征参数和呼吸暂停-低通气指数（AHI），并对积极吸烟者和非吸烟者进行了比较。研究还确定了使用 PAP 治疗 3 个月前后代谢综合征参数的平均变化。研究对象包括 72 名男性和 43 名女性：结果：主动吸烟者和非吸烟者的形态测量值和平均 AHI 没有差异。对治疗前后测量的代谢参数不变、增加或减少的百分比进行分析后发现，与非吸烟者相比，接受过 PAP 治疗的 OSA 活动性吸烟者的瘦素水平呈上升趋势（P=0.034，已对混杂因素进行调整）：结论：非吸烟者血清瘦素水平稳定或下降，而40%的活跃吸烟者瘦素水平升高。因此，尽管 OSA 患者接受了 PAP 治疗，吸烟仍是导致瘦素抵抗的易感因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

8.30

自引率

9.60%

发文量

审稿时长

19 weeks

期刊介绍： The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).