RNAkines are secreted messengers shaping health and disease

Jing Li, Jingwen Fang, Xiaohong Jiang, Yujing Zhang, Antonio Vidal-Puig, Chen-Yu Zhang
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Abstract

Extracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the pathogenesis of various diseases. Given the unique aspects of extracellular ncRNAs, here we propose the term ‘RNAkine’ to describe these recently identified secreted factors. We explore their roles as intercellular modulators, particularly in their ability to regulate metabolism and influence tumorigenesis, highlighting their definition and importance as a distinct class of secreted factors.

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RNAkines 是影响健康和疾病的分泌信使
细胞外非编码 RNA(ncRNA)在细胞间通信中起着至关重要的作用。ncRNA的分泌过程受到高度调控,在不同的生理和病理情况下会产生特定的ncRNA。这些 ncRNA 主要通过细胞外囊泡 (EV) 从起源细胞运输到靶细胞,利用的是内分泌和旁分泌途径。细胞外 ncRNA 的细胞间影响对于维持体内平衡和各种疾病的发病机制至关重要。鉴于细胞外 ncRNA 的独特性,我们在此提出 "RNAkine "一词来描述这些最近发现的分泌因子。我们探讨了它们作为细胞间调节因子的作用,特别是它们调节新陈代谢和影响肿瘤发生的能力,强调了它们作为一类独特的分泌因子的定义和重要性。
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