Vitamin K: New insights related to senescence and cancer metastasis

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2023-12-28 DOI:10.1016/j.bbcan.2023.189057

Anqi Chen , Jialu Li , Nianxuan Shen , Haifeng Huang , Qinglei Hang

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Abstract

Several clinical trials and experimental studies have recently shown that vitamin K (VK) supplementation benefits the human body. Specifically, VK participates in coagulation and is associated with cellular senescence and cancer. VK has a potential anticancer effect in various cancers, such as pancreatic and prostate cancers. Through anti-inflammatory and antioxidant effects, VK can prevent senescence and inhibit cancer metastasis. Therefore, cancer prognosis can be improved by preventing cellular senescence. In addition, VK can inhibit the proliferation, growth, and differentiation of cancer cells through various mechanisms, including induction of c-myc and c-fos genes, regulation of B-cell lymphoma-2 (Bcl-2) and p21 genes, and angiogenesis inhibition. This review aims to discuss the relationship among VK, cellular senescence, and cancer metastasis and thus may improve comprehension of the specific functions of VK in human health. The potential application of VK as an adjuvant therapy for cancer (or in combination with traditional chemotherapy drugs or other vitamins) has also been highlighted.

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维生素 K：与衰老和癌症转移有关的新见解

最近的一些临床试验和实验研究表明，补充维生素 K（VK）对人体有益。具体来说，VK 参与凝血，与细胞衰老和癌症有关。维生素 K 对胰腺癌和前列腺癌等多种癌症具有潜在的抗癌作用。通过抗炎和抗氧化作用，VK 可以防止衰老并抑制癌症转移。因此，通过防止细胞衰老可以改善癌症预后。此外，VK 还能通过多种机制抑制癌细胞的增殖、生长和分化，包括诱导 c-myc 和 c-fos 基因、调节 B 细胞淋巴瘤-2（Bcl-2）和 p21 基因以及抑制血管生成。本综述旨在讨论 VK、细胞衰老和癌症转移之间的关系，从而提高人们对 VK 在人类健康中的特定功能的理解。此外，还强调了 VK 作为癌症辅助疗法（或与传统化疗药物或其他维生素结合使用）的潜在应用。

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.