In vitro studies of a novel liposomal formulation for safe and efficient iron delivery

IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY European Journal of Lipid Science and Technology Pub Date : 2023-12-28 DOI:10.1002/ejlt.202300217
Kamila Szostak-Paluch, Dominik Drabik, Natalia Jędruchniewicz, Mariola Dwornikowska-Dąbrowska
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Abstract

Anemia of chronic diseases is the most popular type of anemia. Treatment of such conditions is based on iron supplementation. However, chronic conditions are accompanied by increased activity of hepcidin, which significantly limits iron absorption from traditional supplementation forms. Modern liposomal technologies allow for efficient encapsulation of macromolecules, which can result in a significant absorption improvement. The presented results show an encapsulation efficiency of more than 90% of iron-dextran complexes, with a decrease in cytotoxicity and reactive oxygen species generation.

Practical Application: These results can be used to prepare novel liposomal iron ion formulation with high encapsulation efficiency due to the appliance of iron(III) oxide complex with dextran.

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用于安全高效递送铁的新型脂质体制剂的体外研究
慢性病贫血是最常见的贫血类型。治疗这类疾病的方法是补充铁剂。然而,慢性病伴随着血红素活性的增加,这大大限制了铁从传统补充剂中的吸收。现代脂质体技术可有效封装大分子,从而显著改善吸收。研究结果表明,右旋糖酐铁复合物的封装效率超过 90%,细胞毒性和活性氧生成均有所降低。
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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
101
审稿时长
6-16 weeks
期刊介绍: The European Journal of Lipid Science and Technology is a peer-reviewed journal publishing original research articles, reviews, and other contributions on lipid related topics in food science and technology, biomedical science including clinical and pre-clinical research, nutrition, animal science, plant and microbial lipids, (bio)chemistry, oleochemistry, biotechnology, processing, physical chemistry, and analytics including lipidomics. A major focus of the journal is the synthesis of health related topics with applied aspects. Following is a selection of subject areas which are of special interest to EJLST: Animal and plant products for healthier foods including strategic feeding and transgenic crops Authentication and analysis of foods for ensuring food quality and safety Bioavailability of PUFA and other nutrients Dietary lipids and minor compounds, their specific roles in food products and in nutrition Food technology and processing for safer and healthier products Functional foods and nutraceuticals Lipidomics Lipid structuring and formulations Oleochemistry, lipid-derived polymers and biomaterials Processes using lipid-modifying enzymes The scope is not restricted to these areas. Submissions on topics at the interface of basic research and applications are strongly encouraged. The journal is the official organ the European Federation for the Science and Technology of Lipids (Euro Fed Lipid).
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Cover Picture: Eur. J. Lipid Sci. Technol. 11/2024 Editorial Board: Eur. J. Lipid Sci. Technol. 11/2024 Contents: Eur. J. Lipid Sci. Technol. 11/2024 One step beyond for CNSL-based plasticizers for PVC: Use of cardol Cover Picture: Eur. J. Lipid Sci. Technol. 10/2024
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