Nutrition counselling and clinical outcomes in HIV: A systematic review and meta-analysis

IF 2.8 3区医学 Q2 INFECTIOUS DISEASES HIV Medicine Pub Date : 2023-12-29 DOI:10.1111/hiv.13603

Temitayo Rebecca Okusanya, Elile Monisola Okoka, Moshood Abiodun Kuyebi, Oluwafemi Temitayo Oyadiran, Temitope Kowe, Ramadhani Abdallah Noor, Moshood Olanrewaju Omotayo, Ajibola Ibraheem Abioye

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Abstract

Background

People living with the HIV (PLHIV) are at an increased risk of various diseases due to a weakened immune system, particularly if they are naïve or poorly adherent to antiretroviral therapy (ART). Nutrients play a critical role in improving immune health, especially among this population. We systematically reviewed the evidence concerning the impact of nutritional counselling on the occurrence of important clinical outcomes among PLHIV.

Methods

Medical literature databases (PubMed, EMBASE and Web of Science) were searched from inception to October 2022 for relevant published studies (n = 12) of nutritional counselling and HIV-related outcomes in adults on ART. Random-effects meta-analyses were conducted when the exposure–outcome relationships were similar in three or more studies.

Results

Although the methodologies of nutritional intervention varied across all studies, overall, the evidence from the meta-analysis indicates a nsignificant positive association between nutrition counselling and improvements in CD4 cell count, body mass index and low-density lipoprotein concentration. However, the existing literature does not provide enough evidence to establish a significant impact of nutrition counselling on other immune, anthropometric, and metabolic outcomes including viral load, weight, and lean mass due to the differences in the study designs.

Conclusion

Well-powered randomized controlled trials are needed that explore the effect of evidence-based, individualized nutrition counselling on HIV-related clinical outcomes.

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营养咨询与 HIV 的临床结果：系统回顾和荟萃分析

艾滋病病毒感染者（PLHIV）由于免疫系统功能减弱，罹患各种疾病的风险也随之增加，尤其是在他们对抗逆转录病毒疗法（ART）尚不适应或依从性较差的情况下。营养素在改善免疫健康方面发挥着至关重要的作用，尤其是在这一人群中。我们系统地回顾了有关营养咨询对艾滋病毒感染者重要临床结果的影响的证据。

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来源期刊

HIV Medicine 医学-传染病学

CiteScore

5.10

自引率

10.00%

发文量

167

审稿时长

6-12 weeks

期刊介绍： HIV Medicine aims to provide an alternative outlet for publication of international research papers in the field of HIV Medicine, embracing clinical, pharmocological, epidemiological, ethical, preclinical and in vitro studies. In addition, the journal will commission reviews and other feature articles. It will focus on evidence-based medicine as the mainstay of successful management of HIV and AIDS. The journal is specifically aimed at researchers and clinicians with responsibility for treating HIV seropositive patients.