Myeloid-derived growth factor and its effects on cardiovascular and metabolic diseases

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2023-12-30 DOI:10.1016/j.cytogfr.2023.12.005
Jinling Xu , Yanzhuo Song , Sheng Ding , Weizhe Duan , Guangda Xiang , Zhongjing Wang
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Abstract

Myeloid-derived growth factor (MYDGF) is a paracrine protein produced by bone marrow-derived monocytes and macrophages. Current research shows that it has protective effects on the cardiovascular system, such as repairing heart tissue after myocardial infarction, enhancing cardiomyocyte proliferation, improving cardiac regeneration after myocardial injury, regulating proliferation and survival of endothelial cells, reducing endothelial cell damage, resisting pressure overload-induced heart failure, as well as protecting against atherosclerosis. Furthermore, regarding the metabolic diseases, MYDGF has effects of improving type 2 diabetes mellitus, relieving non-alcoholic fatty liver disease, alleviating glomerular diseases, and resisting osteoporosis. Herein, we will discuss the biology of MYDGF and its effects on cardiovascular and metabolic diseases.

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髓源性生长因子及其对心血管疾病和代谢疾病的影响
髓源性生长因子(MYDGF)是一种由骨髓单核细胞和巨噬细胞产生的旁分泌蛋白。目前的研究表明,它对心血管系统具有保护作用,如修复心肌梗死后的心脏组织、促进心肌细胞增殖、改善心肌损伤后的心脏再生、调节内皮细胞的增殖和存活、减少内皮细胞损伤、抵抗压力过大引起的心力衰竭以及防止动脉粥样硬化。此外,在代谢性疾病方面,MYDGF 还具有改善 2 型糖尿病、缓解非酒精性脂肪肝、减轻肾小球疾病和预防骨质疏松症的作用。在此,我们将讨论 MYDGF 的生物学特性及其对心血管疾病和代谢疾病的影响。
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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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