Pharmaceutical cocrystals: a rising star in drug delivery applications.

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY Journal of Drug Targeting Pub Date : 2024-12-01 Epub Date: 2024-02-01 DOI:10.1080/1061186X.2023.2300690

Prabhakar Panzade, Anita Wagh, Pratiksha Harale, Sumeet Bhilwade

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Abstract

Pharmaceutical cocrystals, owing to their manifold applications, are acting as bridge between drug discovery and pharmaceutical product development. The ability to scale up pharmaceutical cocrystals through continuous manufacturing approaches offers superior and economic pharmaceutical products. Moreover, cocrystals can be an aid for the nanoparticulate systems to solve the issues related to scale-up and cost. Cocrystals grabbed attention of academic researchers and pharmaceutical scientist due to their potential to target various diseases like cancer. The present review is mainly focussed on the diverse and comprehensive applications of pharmaceutical cocrystals in drug delivery including solubility and dissolution enhancement, improvement of bioavailability of drug, mechanical and flow properties of active pharmaceutical ingredients, controlled/sustained release and colour tuning of API. Besides, phytochemical based cocrystals, multi-drug cocrystals and cocrystals for tumour therapy have been discussed in this review. Additionally, recent progress pertinent to pharmaceutical cocrystals is also included, which may provide future directions to manufacturing and scale-up of cocrystals.

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药用共晶体：药物输送应用领域的后起之秀。

药用共晶体具有多种用途，是药物发现和医药产品开发之间的桥梁。通过连续生产方法放大药用椰壳晶体的能力可提供优质、经济的医药产品。此外，茧晶还可作为纳米颗粒系统的辅助材料，以解决与放大和成本相关的问题。共晶体因其针对癌症等各种疾病的潜力而备受学术研究人员和制药科学家的关注。本综述主要关注药用茧晶在给药方面的多样化和全面应用，包括提高溶解度和溶解度、改善药物的生物利用度、活性药物成分的机械和流动特性、控制/持续释放以及原料药的颜色调节。此外，本综述还讨论了基于植物化学物质的共晶体、多种药物共晶体以及用于肿瘤治疗的共晶体。此外，本综述还介绍了与药用茧晶有关的最新进展，这些进展可为茧晶的制造和放大提供未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.