Clinicopathological characteristics of odontogenic carcinosarcoma: A systematic review

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-01 DOI:10.1111/jop.13502

Karoline Gomes da Silveira, Luiza de Almeida Souto Montenegro, Diana Santana de Albuquerque, Carlos Augusto Pereira do Lago, José Rodrigues Laureano Filho, Ricardo José Holanda de Vasconcellos

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Abstract

Background

The aim of the present systematic review was to summarize evidence on odontogenic carcinosarcoma, analyzing clinical, epidemiological, imaging, histopathological, immunohistochemical, therapeutic, and prognostic features of this tumor.

Materials and Methods

This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searches were performed in the Ovid MEDLINE (Wolters Kluwer), PubMed (National Library of Medicine), Web of Science (Thomson Reuters), Scopus (Elsevier), and LILACS (Latin American and Caribbean Center on Health Sciences Information) databases, without publication date or language restrictions. Case reports or case series of OCS reporting clinical, radiological, and histopathological data that confirmed the diagnosis were selected. The Joanna Briggs Institute—University of Adelaide tool was used for critical appraisal of the included articles.

Results

Odontogenic carcinosarcoma is a rare, aggressive tumor associated with high mortality; however, the metastasis rate is low. The tumor has a male predilection. The mean patient age is 40 years, but there is no predilection for age. The left posterior mandible is the most affected site, but no specific radiographic features have been reported.

Conclusion

Given its rarity, dentists, oral-maxillofacial surgeons, and physicians need to be aware of odontogenic carcinosarcoma in order to increase the diagnostic potential, preventing delays in diagnosis and treatment and thus contributing to lower morbidity of the tumor.

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牙源性癌肉瘤的临床病理特征：系统综述。

背景：本系统综述旨在总结牙源性癌肉瘤的相关证据，分析该肿瘤的临床、流行病学、影像学、组织病理学、免疫组化、治疗和预后特征：本系统综述遵循系统综述和元分析首选报告项目（Preferred Reporting Items for Systematic Reviews and Meta-Analyses，PRISMA）指南。在 Ovid MEDLINE (Wolters Kluwer)、PubMed (National Library of Medicine)、Web of Science (Thomson Reuters)、Scopus (Elsevier) 和 LILACS (Latin American and Caribbean Center on Health Sciences Information) 数据库中进行检索，无出版日期和语言限制。筛选出报告临床、放射学和组织病理学数据并确诊的 OCS 病例报告或系列病例。采用乔安娜-布里格斯研究所（Joanna Briggs Institute）-阿德莱德大学（University of Adelaide）工具对纳入的文章进行批判性评估：牙源性癌肉瘤是一种罕见的侵袭性肿瘤，死亡率高，但转移率低。该肿瘤好发于男性。患者平均年龄为 40 岁，但无年龄偏好。左侧下颌骨后部是受影响最严重的部位，但没有具体的放射学特征报道：鉴于其罕见性，牙科医生、口腔颌面外科医生和内科医生需要了解牙源性癌肉瘤，以提高诊断潜力，防止延误诊断和治疗，从而降低肿瘤的发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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