An analysis on control banding-based methods used for occupational risk assessment of nanomaterials.

IF 3.6 3区 医学 Q3 NANOSCIENCE & NANOTECHNOLOGY Nanotoxicology Pub Date : 2023-12-01 Epub Date: 2024-01-18 DOI:10.1080/17435390.2023.2293141
Soqrat Omari Shekaftik, Nafiseh Nasirzadeh, Mahdi Mohammadiyan, Saman Mohammadpour
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Abstract

Despite all benefits of nanomaterials, their unique characteristics made them an emerging hazard in workplaces, which need to be assessed for their potential risks. So, the aim of this study was to review all the studies conducted on the risk assessment of activities involving nanomaterials with CB-based methods.This study is based on a literature review on databases including Web of science, Scopus, PubMed, and SID. After reviewing and screening studies according to PRISMA, the collected data were meta-analyzed by Comprehensive Meta-Analysis Software. Also, Newcastle-Ottawa checklist was used for quality assessment of the studies. To determine similarity of methods, Cohen's Kappa was used. Sensitivity analysis was used to determine the role of each factor in the risk assessment by using the Crystal Ball tool.There are eight validated methods for risk assessment. Also, some authors used a self-deigned tool based on CB approach. The results of meta-analysis showed that the odds ratio for the risk of activities involved with nanomaterials was 0.654 (high risk). Results of simulation for Nanotool showed that the mean risk level of activities involved with nanomaterials, with a certainty of 95.07%, is moderate (RL3). Moreover, sensitivity analysis showed that the risk was depended on "Hazard band" in all methods except ISO method.The obtained results can be useful in improving existing methods and suggesting new methods. Also, there is a need to design and propose specific methods for risk assessment of incidental and natural nanomaterials.

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分析用于纳米材料职业风险评估的基于控制带的方法。
尽管纳米材料具有各种优点,但其独特的特性使其成为工作场所新出现的危险,需要对其潜在风险进行评估。因此,本研究的目的是回顾所有采用基于 CB 的方法对涉及纳米材料的活动进行风险评估的研究。本研究基于对科学网、Scopus、PubMed 和 SID 等数据库的文献回顾。根据 PRISMA 对研究进行审查和筛选后,利用综合荟萃分析软件对收集到的数据进行了荟萃分析。此外,还使用纽卡斯尔-渥太华核对表对研究进行质量评估。为确定方法的相似性,使用了科恩卡帕(Cohen's Kappa)。使用水晶球工具进行敏感性分析,以确定每个因素在风险评估中的作用。此外,一些作者还使用了基于 CB 方法的自定工具。荟萃分析结果表明,与纳米材料有关的活动风险的几率比为 0.654(高风险)。对 Nanotool 的模拟结果表明,涉及纳米材料的活动的平均风险水平为中等(RL3),确定性为 95.07%。此外,敏感性分析表明,除 ISO 方法外,所有方法的风险都取决于 "危险带"。此外,还需要设计和提出对偶然和天然纳米材料进行风险评估的具体方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nanotoxicology
Nanotoxicology 医学-毒理学
CiteScore
10.10
自引率
4.00%
发文量
45
审稿时长
3.5 months
期刊介绍: Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.
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