Protective Effects of Chia Seeds and Omega-3 Fatty Acid against Cyclophosphamide-Induced Oligospermia in Male Wistar Rats: Potential Risks of Adverse Drug Interaction with Chia Seeds.

IF 2.5 3区 工程技术 Q2 BIOLOGY Yale Journal of Biology and Medicine Pub Date : 2023-12-29 eCollection Date: 2023-12-01 DOI:10.59249/PAEJ4854
Prince B Vaghela, Archana M Navale, Chirangi B Patel, Nishant H Patidar, Prachi D Nahar, Farmi Patel, Zainab Pathan, Barsha Kumari
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引用次数: 0

Abstract

Objectives: The aim of this study was to investigate whether chia (Salvia hispanica) seeds, which are rich in omega-3 fatty acids, amino acids, and vitamins with antioxidant properties, can mitigate the negative effects on male reproductive function caused by cyclophosphamide, a frequently used chemotherapeutic agent. Methods: Male wistar rats are divided into seven groups (n=6). All groups except the normal control (NC) received cyclophosphamide (30mg/kg, i.p.) for the first 5 days. The standard group received clomiphene citrate (0.25 mg/kg, p.o.). Treatment groups T1%, T5%, T10%, and ω-3 received 1%, 5%, and 10% chia seeds in the diet, and 880 mg/kg omega-3 fatty acid (p.o) respectively for 15 days. The effect on the reproductive system was evaluated by analysis of epididymal sperm characteristics, biochemical parameters, and serum testosterone level. Results: Clomiphene citrate improved oligospermia via hormone mediated effect. Chia seeds and omega-3 fatty acid treatment also showed improvement in reproductive parameters including oxidative stress and histological features of the testes. Omega-3 fatty acid treatment was more effective for the prevention of cyclophosphamide toxicity on testes as compared to chia seeds. Nasal bleeding was noted in several animals subjected to chia seed treatment. This occurrence might be attributed to chia seeds' impact on coagulation and/or platelet function, potentially heightened due to chemotherapy associated bone marrow suppression. Conclusions: In our study, chia seeds as well as omega-3 fatty acid treatment were found to be protective against cyclophosphamide-induced reproductive toxicity in rats. However, the adverse effect of hemorrhage associated with drug interaction of chia seeds with cytotoxic chemotherapeutic drugs needs careful attention and further investigation.

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Chia Seeds 和 Omega-3 脂肪酸对环磷酰胺诱导的雄性 Wistar 大鼠少精症的保护作用:奇异籽与药物不良相互作用的潜在风险。
研究目的本研究旨在探讨富含欧米伽-3 脂肪酸、氨基酸和具有抗氧化特性的维生素的奇异籽(西班牙鼠尾草)能否减轻常用化疗药物环磷酰胺对男性生殖功能的负面影响。研究方法雄性wistar大鼠分为7组(n=6)。除正常对照组(NC)外,其他各组在头 5 天均接受环磷酰胺(30 毫克/千克,静脉注射)治疗。标准组接受枸橼酸氯米芬(0.25 毫克/千克,口服)。治疗组T1%、T5%、T10%和ω-3分别在饮食中添加1%、5%和10%的奇亚籽,以及880毫克/千克的ω-3脂肪酸(p.o.),持续15天。通过分析附睾精子特征、生化指标和血清睾酮水平,评估了对生殖系统的影响。结果枸橼酸氯米芬通过激素介导作用改善了少精症。奇异籽和欧米伽-3脂肪酸治疗也改善了生殖参数,包括氧化应激和睾丸组织学特征。与奇异籽相比,欧米伽-3 脂肪酸治疗对预防环磷酰胺对睾丸的毒性更有效。接受奇异籽治疗的几只动物出现了鼻出血。这可能是由于奇异籽对凝血和/或血小板功能的影响,而化疗相关的骨髓抑制可能会增强这种影响。结论:在我们的研究中发现,奇异籽和ω-3脂肪酸处理对环磷酰胺诱导的大鼠生殖毒性具有保护作用。然而,奇异籽与细胞毒性化疗药物相互作用引起的出血不良反应还需要仔细关注和进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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