Deciphering microglia phenotypes in health and disease

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-01-03 DOI:10.1016/j.gde.2023.102146
Christopher D Balak , Claudia Z Han , Christopher K Glass
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Abstract

Microglia are the major immune cells of the central nervous system (CNS) that perform numerous adaptive functions required for normal CNS development and homeostasis but are also linked to neurodegenerative and behavioral diseases. Microglia development and function are strongly influenced by brain environmental signals that are integrated at the level of transcriptional enhancers to drive specific programs of gene expression. Here, we describe a conceptual framework for how lineage-determining and signal-dependent transcription factors interact to select and regulate the ensembles of enhancers that determine microglia development and function. We then highlight recent findings that advance these concepts and conclude with a consideration of open questions that represent some of the major hurdles to be addressed in the future.

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解密健康和疾病中的小胶质细胞表型
小胶质细胞是中枢神经系统(CNS)的主要免疫细胞,可发挥中枢神经系统正常发育和平衡所需的多种适应性功能,但也与神经退行性疾病和行为疾病有关。小胶质细胞的发育和功能受到脑环境信号的强烈影响,这些信号在转录增强子水平上整合在一起,驱动特定的基因表达程序。在这里,我们描述了一个概念框架,说明了系谱决定和信号依赖性转录因子如何相互作用,选择和调控决定小胶质细胞发育和功能的增强子组合。然后,我们重点介绍了推进这些概念的最新发现,最后考虑了代表未来需要解决的一些主要障碍的开放性问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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