Overview of the compromised mucosal integrity in celiac disease

IF 2.9 4区生物学 Q3 CELL BIOLOGY Journal of Molecular Histology Pub Date : 2024-01-02 DOI:10.1007/s10735-023-10175-0

Tannaz Taraz, Mohadeseh Mahmoudi-Ghehsareh, Nastaran Asri, Ehsan Nazemalhosseini-Mojarad, Mostafa Rezaei-Tavirani, Somayeh Jahani-Sherafat, Ali Naseh, Mohammad Rostami-Nejad

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Abstract

Intestinal epithelium is a dynamic cellular layer that lines the small-bowel and makes a relatively impenetrable barrier to macromolecules. Intestinal epithelial cell polarity is crucial in coordinating signalling pathways within cells and mainly regulated by three conserved polarity protein complexes, the Crumbs (Crb) complex, partitioning defective (PAR) complex, and Scribble (Scrib) complex. Polarity proteins regulate the proper establishment of the intercellular junctional complexes including tight junctions (TJs), adherence junctions (AJs), and desmosomes which hold epithelial cells together and play a major role in maintaining intestinal barrier integrity. Impaired intestinal epithelial cell polarity and barrier integrity result in irreversible immune responses, the host- microbial imbalance and intestinal inflammatory disorders. Disassembling the epithelial tight junction and augmented paracellular permeability is a conspicuous hallmark of celiac disease (CD) pathogenesis. There are several dietary components that can improve intestinal integrity and function. The aim of this review article is to summarize current information about the association of polarity proteins and AJC damages with pathogenesis of CD.

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乳糜泻黏膜完整性受损概述

肠上皮是小肠的一个动态细胞层，为大分子提供了一道相对坚不可摧的屏障。肠上皮细胞的极性对协调细胞内的信号通路至关重要，主要由三种保守的极性蛋白复合物调控，即 Crumbs（Crb）复合物、分割缺陷（PAR）复合物和 Scribble（Scrib）复合物。极性蛋白能调节细胞间连接复合体的正常建立，包括紧密连接（TJ）、粘连连接（AJ）和脱膜小体，它们能将上皮细胞固定在一起，在维持肠屏障完整性方面发挥着重要作用。肠上皮细胞极性和屏障完整性受损会导致不可逆的免疫反应、宿主-微生物失衡和肠道炎症性疾病。上皮细胞紧密连接的解体和细胞旁通透性的增强是乳糜泻（CD）发病机制的显著特征。有几种膳食成分可以改善肠道完整性和功能。这篇综述文章旨在总结目前有关极性蛋白和AJC损伤与乳糜泻发病机制相关性的信息。

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来源期刊

Journal of Molecular Histology 生物-细胞生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.