Investigating the progression of preeclampsia through a comprehensive analysis of genes associated with per- and polyfluoroalkyl substances.

IF 3.2 4区医学 Q1 Pharmacology, Toxicology and Pharmaceutics Toxicology Mechanisms and Methods Pub Date : 2024-05-01 Epub Date: 2024-01-02 DOI:10.1080/15376516.2023.2299485

Qiuyan Ge, Ju Zhao, Fujuan Qu

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Abstract

Per- and Polyfluoroalkyl Substances (PFAS) are synthetic chemicals utilized in the production of various products that possess water and dirt-repellent properties. Exposure to PFAS has been linked to numerous diseases, such as cancer and preeclampsia (PE). However, whether PFAS contributes to the advancement of PE remains uncertain. In this study, we conducted an extensive bioinformatics analysis using the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) databases, leading us to discover a connection between PE and four specific PFAS. Moreover, further examination revealed that six genes associated with PFAS exhibited significant diagnostic potential for individuals with PE. By employing receiver operating characteristic (ROC) curves, our PFAS-related gene-based nomogram model demonstrated outstanding predictive efficacy for diagnosing PE. Immune infiltration analysis showed that six PFAS-related genes were significantly associated with the level of immune cell infiltration. The expression of PFAS-related genes in PE patients was confirmed by collecting clinical samples. This research has offered fresh perspectives on comprehending the impact of PFAS on PE, drawing attention to the connection between environmental factors and the risks and development of PE.

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通过全面分析与全氟烷基和多氟烷基物质相关的基因，研究子痫前期的进展。

全氟烷基和多氟烷基物质 (PFAS) 是一种合成化学品，用于生产各种具有防水和防污特性的产品。接触 PFAS 与癌症和子痫前期（PE）等多种疾病有关。然而，全氟辛烷磺酸是否会导致子痫前期的发生仍不确定。在这项研究中，我们利用比较毒物基因组学数据库（CTD）和基因表达总库（GEO）数据库进行了广泛的生物信息学分析，从而发现了 PE 与四种特定 PFAS 之间的联系。此外，进一步研究发现，与 PFAS 相关的六个基因对 PE 患者具有显著的诊断潜力。通过使用接收器操作特征曲线（ROC），我们基于 PFAS 相关基因的提名图模型在诊断 PE 方面表现出了卓越的预测功效。免疫浸润分析表明，6 个 PFAS 相关基因与免疫细胞浸润水平显著相关。通过采集临床样本，证实了 PE 患者中 PFAS 相关基因的表达。这项研究为理解 PFAS 对 PE 的影响提供了新的视角，使人们注意到环境因素与 PE 的风险和发展之间的联系。

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来源期刊

Toxicology Mechanisms and Methods 医学-毒理学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.