DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas

IF 14.3 1区 生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2024-01-03 DOI:10.1080/15548627.2023.2299516
Gamze Bildik, Joshua P. Gray, Weiqun Mao, Hailing Yang, Rumeysa Ozyurt, Vivian R. Orellana, Olivier De Wever, Mark S. Carey, Robert C. Bast, Zhen Lu
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) and low-grade ovarian cancer (LGSOC) are characterized by the prevalence of KRAS oncogene mutations. DIRAS3 is the first endogenous non-RAS protein that hete...
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DIRAS3 在 KRAS 驱动的胰腺癌和卵巢癌中诱导自噬并提高对抗自噬疗法的敏感性
胰腺导管腺癌(PDAC)和低级别卵巢癌(LGSOC)的特点是普遍存在KRAS癌基因突变。DIRAS3是第一种内源性非RAS蛋白,它能抑制KRAS基因突变。
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来源期刊
Autophagy
Autophagy 生物-细胞生物学
CiteScore
21.30
自引率
2.30%
发文量
277
审稿时长
1 months
期刊介绍: Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.
期刊最新文献
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