Maged Alkanad, Umme Hani, Annegowda H V, Mohammed Ghazwani, Nazima Haider, Riyaz Ali M. Osmani, Pandareesh M D, Hamsalakshmi, Rajeev Bhat
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引用次数: 0
Abstract
With the rising prevalence of diabetes and its association with cognitive impairment, interest in the use of dietary alkaloids and other natural products has grown significantly. Understanding how these compounds manage diabetic cognitive dysfunction (DCD) is crucial. This comprehensive review explores the etiology of DCD and the effects of alkaloids in foods and dietary supplements that have been investigated as DCD therapies. Data on how dietary alkaloids like berberine, trigonelline, caffeine, capsaicin, 1-deoxynojirimycin, nuciferine, neferine, aegeline, tetramethylpyrazine, piperine, and others regulate cognition in diabetic disorders were collected from PubMed, Research Gate, Web of Science, Science Direct, and other relevant databases. Dietary alkaloids could improve memory in behavioral models and modulate the mechanisms underlying the cognitive benefits of these compounds, including their effects on glucose metabolism, gut microbiota, vasculopathy, neuroinflammation, and oxidative stress. Evidence suggests that dietary alkaloids hold promise for improving cognition in diabetic patients and could open exciting avenues for future research in diabetes management.
随着糖尿病发病率的上升及其与认知障碍的关联,人们对使用膳食生物碱和其他天然产品的兴趣大增。了解这些化合物如何控制糖尿病认知功能障碍(DCD)至关重要。这篇综述探讨了糖尿病认知功能障碍的病因,以及作为糖尿病认知功能障碍疗法研究的食物和膳食补充剂中生物碱的作用。本文从 PubMed、Research Gate、Web of Science、Science Direct 和其他相关数据库中收集了有关小檗碱、三尖杉碱、咖啡因、辣椒碱、1-脱氧野尻霉素、核iferine、奈菲林、苧麻碱、四甲基吡嗪、胡椒碱等膳食生物碱如何调节糖尿病患者认知能力的数据。膳食生物碱可以改善行为模型中的记忆,并调节这些化合物对认知有益的机制,包括对葡萄糖代谢、肠道微生物群、血管病变、神经炎症和氧化应激的影响。有证据表明,膳食生物碱有望改善糖尿病患者的认知能力,并为未来的糖尿病管理研究开辟了令人兴奋的途径。
期刊介绍:
BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease.
The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements.
In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.