Effect of local injection of injectable platelet-rich fibrin on bone remodeling during orthodontic tooth movement in dogs.

Q2 Dentistry Dental Research Journal Pub Date : 2023-11-27 eCollection Date: 2023-01-01

Atefeh Tabibi, Masood Feizbakhsh, Nasim Esnaashari, Seyed Mohammad Razavi

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Abstract

Background: This study aimed to assess the effect of local injection of injectable platelet-rich fibrin (i-PRF) on bone remodeling during orthodontic tooth movement in dogs.

Materials and methods: In this animal study, the maxillary first premolars of four adult male mixed-breed dogs were bilaterally extracted, and a nickel-titanium closed coil spring with 150 g force was placed between the canine and second premolar teeth. One quadrant of the maxilla was randomly selected as the test quadrant, and 0.5 cc i-PRF was injected into the periodontal ligament (PDL) around the second premolar at 1, 21, and 42 days. The other quadrant served as the control group and received saline injections. The dogs were sacrificed after 63 days, histological sections were prepared, and changes in bone remodeling were assessed by comparing the percentage of osteogenesis and number of osteoblasts and osteoclasts between the two groups by the Wilcoxon and Mann-Whitney U-tests (α = 0.05).

Results: The percentage of osteogenesis (16.0% ± 4.96% in i-PRF and 13.5% ± 4.43% in the control), the percentage of newly formed lamellar bone (10.25% ± 2.87% in i-PRF and 8.75% ± 2.36% in the control), the percentage of woven bone (5.75% ± 2.21% in i-PRF and 4.75% ± 2.36% in the control), the number of osteoblasts (15.0 ± 3.46 in i-PRF and 11.75 ± 2.36 in the control), and the number of osteoclasts (11.25 ± 4.34 in i-PRF and 6.25 ± 2.62 in the control) were not significantly different between the two groups (P > 0.05).

Conclusion: PDL injection of i-PRF around the second premolars of dogs under orthodontic force had no significant effect on bone remodeling.

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局部注射富血小板纤维蛋白对狗牙齿矫正过程中骨重塑的影响。

背景：本研究旨在评估局部注射富血小板纤维蛋白（i-PRF）对犬牙齿矫正过程中骨重塑的影响：在这项动物研究中，四只成年雄性混种犬的上颌第一前臼齿被双侧拔除，在犬齿和第二前臼齿之间放置了一个力为 150 g 的镍钛闭合螺旋弹簧。随机选取上颌骨的一个象限作为试验象限，分别在 1 天、21 天和 42 天将 0.5 cc i-PRF 注入第二前臼齿周围的牙周韧带 (PDL)。另一个象限作为对照组，注射生理盐水。狗在 63 天后处死，制备组织学切片，并通过 Wilcoxon 和 Mann-Whitney U 检验（α = 0.05）比较两组的成骨百分比、成骨细胞和破骨细胞数量，评估骨重塑的变化：i-PRF组的成骨率（16.0% ± 4.96%）和对照组的成骨率（13.5% ± 4.43%）、新形成的片状骨比例（i-PRF组为10.25% ± 2.87%，对照组为8.75% ± 2.36%）、编织骨比例（i-PRF组为5.75% ± 2.21%，对照组为4.75% ± 2.36%）、成骨细胞数量（i-PRF 为 15.0 ± 3.46，对照组为 11.75 ± 2.36）和破骨细胞数量（i-PRF 为 11.25 ± 4.34，对照组为 6.25 ± 2.62）在两组间无显著差异（P > 0.05）：结论：在正畸犬第二前臼齿周围注射 i-PRF 的 PDL 对骨重塑无明显影响。

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来源期刊

Dental Research Journal Dentistry-Dentistry (all)

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

52 weeks

期刊介绍： Dental Research Journal, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Bimonthly print on demand compilation of issues published. The journal’s full text is available online at http://www.drjjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Dentistry. Articles with clinical interest and implications will be given preference.