Mitochondrial Stress and Mitokines: Therapeutic Perspectives for the Treatment of Metabolic Diseases.

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & Metabolism Journal Pub Date : 2024-01-01 Epub Date: 2024-01-03 DOI:10.4093/dmj.2023.0115
Benyuan Zhang, Joon Young Chang, Min Hee Lee, Sang-Hyeon Ju, Hyon-Seung Yi, Minho Shong
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Abstract

Mitochondrial stress and the dysregulated mitochondrial unfolded protein response (UPRmt) are linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Mitokines, signaling molecules released by mitochondrial stress response and UPRmt, are crucial mediators of inter-organ communication and influence systemic metabolic and physiological processes. In this review, we provide a comprehensive overview of mitokines, including their regulation by exercise and lifestyle interventions and their implications for various diseases. The endocrine actions of mitokines related to mitochondrial stress and adaptations are highlighted, specifically the broad functions of fibroblast growth factor 21 and growth differentiation factor 15, as well as their specific actions in regulating inter-tissue communication and metabolic homeostasis. Finally, we discuss the potential of physiological and genetic interventions to reduce the hazards associated with dysregulated mitokine signaling and preserve an equilibrium in mitochondrial stress-induced responses. This review provides valuable insights into the mechanisms underlying mitochondrial regulation of health and disease by exploring mitokine interactions and their regulation, which will facilitate the development of targeted therapies and personalized interventions to improve health outcomes and quality of life.

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线粒体压力和丝裂蛋白:治疗代谢性疾病的治疗前景》。
线粒体应激反应和线粒体折叠蛋白反应(UPRmt)失调与多种疾病有关,包括代谢紊乱、神经退行性疾病和癌症。线粒体应激反应和 UPRmt 释放的信号分子--丝裂蛋白是器官间交流的重要媒介,影响着全身代谢和生理过程。在这篇综述中,我们将全面概述丝裂原素,包括运动和生活方式干预对它们的调控,以及它们对各种疾病的影响。我们重点介绍了与线粒体压力和适应有关的有丝分裂激素的内分泌作用,特别是成纤维细胞生长因子 21 和生长分化因子 15 的广泛功能,以及它们在调节组织间交流和代谢平衡方面的特殊作用。最后,我们讨论了生理和遗传干预的潜力,以减少与失调的丝裂蛋白激酶信号相关的危害,并保持线粒体应激反应的平衡。本综述通过探讨丝裂蛋白激酶的相互作用及其调控,为线粒体调控健康和疾病的机制提供了宝贵的见解,这将促进靶向疗法和个性化干预措施的开发,从而改善健康状况和生活质量。
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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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