Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation.

IF 4.2 3区 医学 Q2 ONCOLOGY Clinical & Experimental Metastasis Pub Date : 2024-02-01 Epub Date: 2024-01-05 DOI:10.1007/s10585-023-10258-y
Sachin G Nair, Sonu Benny, Wesley M Jose, Aneesh T P
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Abstract

The prevailing treatment stratagem in cancer therapy still challenges the dilemma of a probable metastatic spread following an initial diagnosis. Including an anti-metastatic agent demands a significant focus to overrule the incidence of treatment failures. Adrenergic stimulation underlying the metastatic spread paved the way for beta blockers as a breakthrough in repurposing as an anti-metastatic agent. However, the current treatment approach fails to fully harness the versatile potential of the drug in inhibiting probable metastasis. The beta blockers were seen to show a myriad of grip over the pro-metastatic and prognostic parameters of the patient. Novel interventions in immune therapy, onco-hypertension, surgery-induced stress, induction of apoptosis and angiogenesis inhibition have been used as evidence to interpret our objective of discussing the potential adjuvant role of the drug in the existing anti-cancer regimens. Adding weight to the relative incidence of onco-hypertension as an unavoidable side effect from chemotherapy, the slot for an anti-hypertensive agent is necessitated, and we try to suggest beta-blockers to fill this position. However, pointing out the paucity in the clinical study, we aim to review the current status of beta blockers under this interest to state how the drug should be included as a drug of choice in every patient undergoing cancer treatment.

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β-受体阻滞剂辅助疗法作为一种前瞻性的抗转移疗法,具有心脏肿瘤学调节作用。
癌症治疗中的主流治疗策略仍然面临着初步诊断后可能出现转移扩散的难题。要克服治疗失败的发生率,必须重点关注抗转移药物。肾上腺素能刺激是转移扩散的基础,这为β受体阻滞剂作为抗转移药物的重新用途突破铺平了道路。然而,目前的治疗方法未能充分利用这种药物在抑制可能的转移方面的多功能潜力。人们发现,β受体阻滞剂对患者的促转移和预后参数具有多种控制作用。免疫疗法、肿瘤高血压、手术引起的应激、诱导细胞凋亡和血管生成抑制等方面的新干预措施被用作证据,以解释我们讨论该药物在现有抗癌方案中的潜在辅助作用这一目标。作为化疗不可避免的副作用,合并高血压的发生率相对较高,因此需要一种抗高血压药物,我们尝试建议使用β-受体阻滞剂来填补这一空缺。然而,鉴于临床研究的匮乏,我们旨在回顾一下β受体阻滞剂在这一领域的现状,并说明该药物应如何作为每一位接受癌症治疗的患者的首选药物。
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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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