How do we make progress in phenotyping patients with lower urinary tract such as overactive bladder and underactive detrusor, including using urine markers and microbiome data, to personalize therapy? ICI-RS 2023-Part 2.

IF 1.8 3区医学 Q3 UROLOGY & NEPHROLOGY Neurourology and Urodynamics Pub Date : 2024-08-01 Epub Date: 2024-01-04 DOI:10.1002/nau.25379

Enrico Finazzi Agrò, Eleonora Rosato, Adrian Wagg, Sanjay Sinha, Claudia Fede Spicchiale, Maurizio Serati, Vito Mancini, Mathijs de Rijk, Tufan Tarcan, Alan Wein, Paul Abrams, George Bou Kheir

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Abstract

Introduction: Overactive bladder (OAB) and underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.

Objectives: The aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.

Methods: A compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU using urodynamic tests, functional neuro-imaging, urinary markers, and microbiome.

Results and conclusions: The article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract (LUT) symptoms, such as OAB and UAB. The intricate interplay between the LUT and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one-size-fits-all approach.

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我们如何利用尿液标记物和微生物组数据等方法，对膀胱过度活动症和逼尿肌功能减退症等下尿路患者进行表型分析，以实现个性化治疗？ICI-RS 2023-第 2 部分。

导言：膀胱过度活动症（OAB）和膀胱逼尿肌活动不足（UAB）可能与代谢综合征、情感障碍、性激素缺乏、泌尿微生物群变化、功能性胃肠道疾病或自主神经系统功能障碍有关：本智囊团旨在为如何调查 OAB 和/或逼尿肌张力不足（DU）患者提供指导，以便更好地阐明潜在的病理生理学，并在可能的情况下进行个性化治疗：方法：根据目前与使用尿动力学测试、功能神经影像学、尿液标记物和微生物组对 OAB 或 DU 患者进行表型分析相关的证据进行讨论汇编：文章强调了采用全面而有针对性的方法对有下尿路（LUT）症状（如尿崩症和尿失禁）的患者进行表型的重要意义。下尿路与代谢、神经、心理和胃肠道等各种因素之间错综复杂的相互作用可确定独特的下尿路特征，从而使个性化疗法取代 "一刀切 "的方法。

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来源期刊

Neurourology and Urodynamics 医学-泌尿学与肾脏学

CiteScore

4.30

自引率

10.00%

发文量

231

审稿时长

4-8 weeks

期刊介绍： Neurourology and Urodynamics welcomes original scientific contributions from all parts of the world on topics related to urinary tract function, urinary and fecal continence and pelvic floor function.