The Ability to Voluntarily Regulate Theta Band Activity Affects How Pharmacological Manipulation of the Catecholaminergic System Impacts Cognitive Control.

IF 4.5 2区 医学 Q1 CLINICAL NEUROLOGY International Journal of Neuropsychopharmacology Pub Date : 2024-01-01 DOI:10.1093/ijnp/pyae003
Astrid Prochnow, Moritz Mückschel, Elena Eggert, Jessica Senftleben, Christian Frings, Alexander Münchau, Veit Roessner, Annet Bluschke, Christian Beste
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Abstract

Background: The catecholaminergic system influences response inhibition, but the magnitude of the impact of catecholaminergic manipulation is heterogeneous. Theoretical considerations suggest that the voluntary modulability of theta band activity can explain this variance. The study aimed to investigate to what extent interindividual differences in catecholaminergic effects on response inhibition depend on voluntary theta band activity modulation.

Methods: A total of 67 healthy adults were tested in a randomized, double-blind, cross-over study design. At each appointment, they received a single dose of methylphenidate or placebo and performed a Go/Nogo task with stimuli of varying complexity. Before the first appointment, the individual's ability to modulate theta band activity was measured. Recorded EEG data were analyzed using temporal decomposition and multivariate pattern analysis.

Results: Methylphenidate effects and voluntary modulability of theta band activity showed an interactive effect on the false alarm rates of the different Nogo conditions. The multivariate pattern analysis revealed that methylphenidate effects interacted with voluntary modulability of theta band activity at a stimulus processing level, whereas during response selection methylphenidate effects interacted with the complexity of the Nogo condition.

Conclusions: The findings reveal that the individual's theta band modulability affects the responsiveness of an individual's catecholaminergic system to pharmacological modulation. Thus, the impact of pharmacological manipulation of the catecholaminergic system on cognitive control most likely depends on the existing ability to self-modulate relevant brain oscillatory patterns underlying the cognitive processes being targeted by pharmacological modulations.

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自愿调节θ波段活动的能力会影响对儿茶酚胺能系统的药物治疗对认知控制的影响。
背景:儿茶酚胺能系统会影响反应抑制,但儿茶酚胺能操作的影响程度却不尽相同。理论上认为,θ波段活动的自愿可调控性可以解释这种差异。本研究旨在探讨儿茶酚胺能对反应抑制作用的个体间差异在多大程度上取决于θ波段活动的自愿调节:方法:67 名健康成年人接受了随机、双盲、交叉研究设计的测试。在每次预约时,他们都会接受单剂量的哌醋甲酯或安慰剂,并在不同复杂度的刺激下完成 Go/Nogo 任务。在第一次约见之前,对患者调节θ波段活动的能力进行了测量。记录的脑电图数据通过时间分解和多变量模式分析(MVPA)进行了分析:结果:哌醋甲酯效应和θ波段活动的自主可调控性对不同 Nogo 条件下的误报率有交互影响。MVPA显示,哌醋甲酯效应与θ波段活动的自愿可调控性在刺激加工层面上相互作用,而在反应选择过程中,哌醋甲酯效应与Nogo条件的复杂性相互作用:研究结果表明,个体的θ波段可调控性会影响个体儿茶酚胺能系统对药物调控的反应性。因此,对儿茶酚胺能系统的药理调控对认知控制的影响很可能取决于现有的自我调节能力,而自我调节能力又是药理调控所针对的认知过程的基础。
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来源期刊
CiteScore
8.40
自引率
2.10%
发文量
230
审稿时长
4-8 weeks
期刊介绍: The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.
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