Developing recombinant antibodies by phage display technology to neutralize viral infectious diseases

IF 2.7 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS SLAS Discovery Pub Date : 2024-01-03 DOI:10.1016/j.slasd.2024.01.001

Mujahed I. Mustafa , Ahmed Mohammed

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Abstract

The use of recombinant antibodies developed through phage display technology offers a promising approach for combating viral infectious diseases. By specifically targeting antigens on viral surfaces, these antibodies have the potential to reduce the severity of infections or even prevent them altogether. With the emergence of new and more virulent strains of viruses, it is crucial to develop innovative methods to counteract them. Phage display technology has proven successful in generating recombinant antibodies capable of targeting specific viral antigens, thereby providing a powerful tool to fight viral infections. In this mini-review article, we examine the development of these antibodies using phage display technology, and discuss the associated challenges and opportunities in developing novel treatments for viral infectious diseases. Furthermore, we provide an overview of phage display technology. As these methods continue to evolve and improve, novel and sophisticated tools based on phage display and peptide display systems are constantly emerging, offering exciting prospects for solving scientific, medical, and technological problems related to viral infectious diseases in the near future.

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利用噬菌体展示技术开发重组抗体，中和病毒性传染病。

利用噬菌体展示技术开发的重组抗体为防治病毒性传染病提供了一种前景广阔的方法。通过特异性靶向病毒表面的抗原，这些抗体有可能减轻感染的严重程度，甚至完全预防感染。随着新病毒和毒性更强的病毒株的出现，开发创新的抗病毒方法至关重要。事实证明，噬菌体展示技术能成功产生针对特定病毒抗原的重组抗体，从而为对抗病毒感染提供了强有力的工具。在这篇微型综述文章中，我们研究了利用噬菌体展示技术开发这些抗体的情况，并讨论了开发新型病毒性传染病治疗方法的相关挑战和机遇。此外，我们还概述了噬菌体展示技术。随着这些方法的不断发展和改进，基于噬菌体展示和多肽展示系统的新型复杂工具不断涌现，为在不久的将来解决与病毒性传染病有关的科学、医学和技术问题提供了令人振奋的前景。

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来源期刊

SLAS Discovery Chemistry-Analytical Chemistry

CiteScore

7.00

自引率

3.20%

发文量

审稿时长

39 days

期刊介绍： Advancing Life Sciences R&D: SLAS Discovery reports how scientists develop and utilize novel technologies and/or approaches to provide and characterize chemical and biological tools to understand and treat human disease. SLAS Discovery is a peer-reviewed journal that publishes scientific reports that enable and improve target validation, evaluate current drug discovery technologies, provide novel research tools, and incorporate research approaches that enhance depth of knowledge and drug discovery success. SLAS Discovery emphasizes scientific and technical advances in target identification/validation (including chemical probes, RNA silencing, gene editing technologies); biomarker discovery; assay development; virtual, medium- or high-throughput screening (biochemical and biological, biophysical, phenotypic, toxicological, ADME); lead generation/optimization; chemical biology; and informatics (data analysis, image analysis, statistics, bio- and chemo-informatics). Review articles on target biology, new paradigms in drug discovery and advances in drug discovery technologies. SLAS Discovery is of particular interest to those involved in analytical chemistry, applied microbiology, automation, biochemistry, bioengineering, biomedical optics, biotechnology, bioinformatics, cell biology, DNA science and technology, genetics, information technology, medicinal chemistry, molecular biology, natural products chemistry, organic chemistry, pharmacology, spectroscopy, and toxicology. SLAS Discovery is a member of the Committee on Publication Ethics (COPE) and was published previously (1996-2016) as the Journal of Biomolecular Screening (JBS).