Evaluation of the Hepatotoxicity Induced by Captopril and Enalapril in Rat Liver: A Comparative Study

Abstract

The aim of this study was to look into the toxicity of captopril and enalapril in high doses in the liver. The animals in this experiment were divided into five groups of ten each, with the first group serving as a control group, receiving only distilled water, the second and thrird groups receiving doses of captopril 10 and 20%, and the fourth and fifth groups receiving doses of enalapril 10 and 20%. The dose is taken orally once every three days for four weeks. After one week, samples were collected, and then again four weeks later. After one week of treatment with Enalapril 20%, biochemical testing revealed significant elevations in ALT and AST. After 1 and 4 weeks of treatment with Enalapril 20%, there was a decrease in glutathione and an increase in malondialdehyde, whereas captopril 20% and Enalapril 10 and 20% significantly raised malondialdehyde levels. Rats given captopril 20% revealed diffuse vacuolar degeneration. The 10% Enalapril group experienced similar symptoms, however the 20% Enalapril group experienced vacuolar degeneration,