The effect of substituted aminoalkylaminoanthraquinones on eukaryotic cells.

Drug design and delivery Pub Date : 1989-06-01
J Katzhendler, G Bar-Ad, M Haran, K F Gean, Z Tashma, I Ringel, A Ramu, U Bachrach
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Abstract

Nine aminoalkylaminoanthraquinones (I-IX) were evaluated for their cytotoxic potency against normal and malignant mammalian cells. The 1.8-di-(aminopropylamino) derivative (VIII) exhibited significant activity against several tumor cell systems and had some selectivity. The toxicity of this compound was also tested in growing chick embryos.

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取代氨基烷基氨基蒽醌对真核细胞的影响。
研究了9种氨基烷基氨基蒽醌(I-IX)对正常和恶性哺乳动物细胞的细胞毒性。1.8-二(氨基丙基)衍生物(VIII)对几种肿瘤细胞系统具有显著的活性和一定的选择性。这种化合物的毒性也在生长中的小鸡胚胎中进行了测试。
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