Exploring CRISPR/Cas9 Gene Editing Applications for Enhancing Disease Resistance in Sugar Beet

IF 2.3 Q1 AGRICULTURE, MULTIDISCIPLINARY ACS agricultural science & technology Pub Date : 2023-12-26 DOI:10.1021/acsagscitech.3c00193
Varucha Misra, Himanshu Pandey and A.K. Mall*, 
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Abstract

Sugar beet, an important sugar crop utilized for the production of beet sugar, fulfills the world’s sugar demands to about 25%, accompanying cane sugar. The production of sugar beet encounters significant challenges attributed to devastating diseases that result in a decreased crop yield. Disease-resistant varieties are key to mitigating productivity losses traditionally developed through conventional breeding. However, the advent of CRISPR/Cas9 genome editing has accelerated the creation of resistant sugar beet varieties by enabling precise genetic modifications. This advanced technology offers an effective approach to combat bacterial, fungal, and viral pathogens, leading to the development of sugar beet varieties with varying degrees of resistance. The paper elucidates the revolutionary impact of CRISPR/Cas9 on sugar beet, revealing essential regulators of disease resistance and providing insights into interactions with pathogens and the sugar beet microbiome. The integration of CRISPR/Cas9 with other techniques opens novel avenues for understanding and developing disease-resistant sugar beet varieties, marking a significant advancement in the field.

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探索 CRISPR/Cas9 基因编辑在增强甜菜抗病性中的应用
甜菜是一种重要的糖料作物,用于生产甜菜糖,与蔗糖一起满足了全球约 25% 的食糖需求。甜菜生产面临着巨大挑战,毁灭性病害导致作物减产。抗病品种是减轻产量损失的关键,传统上是通过传统育种方法培育出来的。然而,CRISPR/Cas9 基因组编辑技术的出现,通过实现精确的基因修饰,加速了抗病甜菜品种的培育。这一先进技术提供了对抗细菌、真菌和病毒病原体的有效方法,从而培育出具有不同抗性的甜菜品种。论文阐明了 CRISPR/Cas9 对甜菜的革命性影响,揭示了抗病性的基本调节因子,并深入探讨了与病原体和甜菜微生物组的相互作用。CRISPR/Cas9 与其他技术的整合为了解和开发抗病甜菜品种开辟了新途径,标志着该领域的重大进展。
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