Computational and Toxicological Evaluation of Thiamethoxam as Nicotinic Acetylcholine Receptor Modulator Against Cowpea Aphid, Aphis craccivora Koch.

Abstract

interaction with AChBP than the co-crystalized ligand (imidacloprid) and good alignment in the active site. THIA indicated different variations in the activities of tested enzymes. Where, aphids treated with LC 50 of THIA increased the biochemical activities of acetylcholinesterase, antioxidant enzymes and peroxidases while decreasing the activity of alpha esterase, carboxylesterase (CarE), glutathione S-transferase and catalase. Therefore, this compound is efficient against sap-sucking pests with good irreversible and specific binding interaction with nicotinic acetylcholine receptor (nAChR) and, consequently, low mammalian toxicity. So, THIA is considered a favourable agent for the management of insect pests.