Assessment of Serum Protein Carbonyls and Glycemic Biomarkers in Patients with Type 2 Diabetic Proliferative Retinopathy

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-13 DOI:10.21608/eajbsc.2023.329310

Zaid Neamah, Omar bdul Rasheed, Alyaa Kareem

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Abstract

Purpose: A case-control study was conducted to evaluate the role of protencarponyls and glycemic biomarkers in type two diabetic patients with proliferative diabetic retinopathy (PDR) .Materials and Methods: a case-control study includes a comparison between 3 groups, (40 healthy persons ) as a control compared with (40 type-2 diabetic patients without proliferative retinopathy) and (40 diabetic patients with proliferative retinopathy) serum PC were determined with ELISA while glycemic biomarkers FBS, HbA1c was determined by spectrophotometry method ( autoanlyser technique) . Result : PC serum level and FBS, HbA1c statistically significantly increased among the study groups, the highest level in PDR patients when compared with control groups and T2M Patients without RP. Conclusion : Protein carbonyls are increased significantly in both T2DM without PDR and PDR patients compared with healthy people ( control ).FBS and HbA1c decreased significantly in both T2DM without PDR and PDR patients compared with healthy people ( control ).

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评估 2 型糖尿病增殖性视网膜病变患者的血清蛋白羰基和血糖生物标志物

目的：本研究进行了一项病例对照研究，以评估增殖性糖尿病视网膜病变（PDR）的二型糖尿病患者中原癌基因和血糖生物标志物的作用。材料与方法：病例对照研究包括三组之间的比较，即以（40 名健康人）为对照组与（40 名无增殖性视网膜病变的二型糖尿病患者）和（40 名有增殖性视网膜病变的糖尿病患者）进行比较，用酶联免疫吸附法测定血清 PC，用分光光度法（自动分析仪技术）测定血糖生物标志物 FBS 和 HbA1c。结果：与对照组和无 RP 的 T2M 患者相比，PDR 患者的血清 PC 水平、FBS 和 HbA1c 在统计上明显升高。结论：与健康人（对照组）相比，无 PDR 的 T2DM 患者和 PDR 患者的蛋白质羰基都明显增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology

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