Glass and Glass-Ceramic Porous Materials for Biomedical Applications

Olga Kędzia, M. Lubas, Agata Dudek
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Abstract

Abstract Biosilicate glasses and glass-ceramic materials obtained on their basis are an important research area in tissue engineering due to their ability to regenerate bones. The most important features of bioactive glasses include: the ability to biodegrade and high bioactivity. Appropriate porosity, pore size, surface structure and topography, chemical composition and ion release kinetics, as well as mechanical properties enable the adhesion of mesenchymal cells and their differentiation towards osteoblast cells and stimulate further proliferation and angiogenesis. This study concerns the subject of bioglass, in particular Bioglass 45S5 and glass-crystalline porous materials in the context of their properties enabling the reconstruction of bone tissue and possible applications. The article addresses crucial issues of shaping the properties of glass and glasscrystalline porous structures by introducing changes in their composition and the method of their production, and also discusses the importance of foaming agents.
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用于生物医学应用的玻璃和玻璃陶瓷多孔材料
摘要 生物硅酸盐玻璃和在其基础上获得的玻璃陶瓷材料具有再生骨骼的能力,是组织工程学的一个重要研究领域。生物活性玻璃最重要的特征包括:生物降解能力和高生物活性。适当的孔隙率、孔径大小、表面结构和形貌、化学成分和离子释放动力学以及机械性能可使间充质细胞粘附并向成骨细胞分化,刺激细胞进一步增殖和血管生成。本研究涉及生物玻璃,特别是生物玻璃 45S5 和玻璃晶体多孔材料的特性,这些特性有助于骨组织的重建和可能的应用。文章探讨了通过改变玻璃和玻璃晶体多孔结构的成分和生产方法来塑造其特性的关键问题,还讨论了发泡剂的重要性。
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