Comparison Between Tamsulosin and Oxybutynin in Relieving Ureteral Stent Related Symptoms

Abstract

One handred cases with unilateral ureteral stent insertion were randomized into four groups; given placebo (25 patients), Oxybutynin 5mg once daily (25 patients), Tamsulosin 0.4mg once daily (25 patients) or combination respectively. All patients received the drugs for three weeks and completed the symptom questionnaire and quality of life questionnaire one week after stent insertion and one week after stent removal. There was no significant difference in the efficacy between Tamsulosin and Oxybutynin in relieving urgency (9 patients, 9 patients respectively), frequency (7 patients, 9 patients respectively) and dysuria (11 patients, 9 patients respectively) with the superiority of combination therapy (12 patients, 16 patients, 17 patients respectively)( P-values: 0.01, 0.001, 0.001 respectively). For relieving abdominal pain, Tamsulosin was more efficacious than Oxybutynin (8 patients versus 5 patients) with the superiority of the combination therapy (12 patients) (P-value: 0.001). For relieving hematuria, Tamsulosin and combination therapy were comparable and both superior to Oxybutynin with a P-value 0.001. For improving quality of life, both Tamsulosin and Oxybutynin were comparable (9 patients, 9 patients) with superiority of combination therapy (15 patients) with a P-value 0.001.