Epidemiological Differences in Dyspepsia: A Comparative Analysis of Clinical and Endoscopic Parameters Between European Union and Turkish Patients

Abstract

Objective: Dyspepsia, a common gastrointestinal disorder, is characterized by persistent or recurrent pain or discomfort centered in the upper abdomen. It often presents with symptoms such as bloating, belching, and nausea. Understanding the epidemiological variations in dyspepsia between EU and Turkish patients can provide valuable insights into potential factors influencing this condition's clinical and endoscopic profiles across different populations. This study aimed to retrospectively examine and compare haematological, biochemical, and endoscopic biopsy parameters among dyspeptic patients from European Union (EU) countries and domestic regions. Material and Methods: e conducted an analysis involving 149 dyspeptic patients, comprising 62 individuals from the European Union (EU) and 87 from Turkey. Data pertaining to hemogram, biochemical parameters, and endoscopic biopsy findings (with a focus on Helicobacter pylori colonization, intestinal metaplasia, and gastric atrophy) were systematically compared between the two groups.zz Results: The study revealed a significantly higher incidence of Helicobacter pylori colonization in the Turkish cohort compared to their EU counterparts. Moreover, variations in hematological and biochemical markers were observed, indicating potential regional and lifestyle differences that may influence dyspeptic symptoms. Conclusion: This study highlights significant epidemiological differences in dyspeptic presentations, particularly the higher prevalence of Helicobacter pylori colonisation in Turkish patients compared to those in the EU. These findings underscore the need for tailored clinical approaches considering regional health determinants in dyspeptic patients.