Non-target analysis of livestock products and feed for residues of drugs, pesticides, mycotoxins and their metabolites by high-resolution mass spectrometry (a review)

Abstract

A review of techniques of non-target analysis for simultaneous identification and determination of veterinary drugs, pesticides, mycotoxins, their metabolites, and substances of chemical transformation in livestock products using liquid chromatography and high-resolution mass spectrometry is presented. Some limitations of the approach are noted, such as the necessity of using common extraction conditions, the possibility of analyte transformations during the sample preparation, false positive results for isobaric and isomeric compounds, and the lack of spectral data for previously unexplored substances. However, the method is the most promising tool for the determination of pollutants not identified in the targeted analysis, as in the case of multicomponent screening of food and raw materials, and in the study of the parent compounds transformation.