Neuroimaging Abnormalities in Severe Acute Respiratory Syndrome Coronavirus 2 Infected are More Diverse than Previously Thought and Depend on the Methods Used

Abstract

We read with interest the articleby Tiwari et al who reported on a retrospective study of 180 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients who underwent neuroimaging in a single Indian center between March 2020 and May 2021. 1 The most frequently detected neuroimaging abnormality was ischemic stroke ( n ¼ 77), followed by bleeding ( n ¼ 22), hypoxic lesions ( n ¼ 5), cerebellitis ( n ¼ 3), demyelination ( n ¼ 1), encephalitis ( n ¼ 1), acute hemorrhagic necrotizing encephalitis ( n ¼ 1), transverse myelitis ( n ¼ 1), cytotoxic lesion of the corpus callosum ( n ¼ 1), Guillain – Barre syndrome ( n ¼ 1), and microbleeds ( n ¼ 1). 1 The study is excellent but has limitations that should be discussed. The fi rst constraint is the inclusion criterion. According to the method part, patients with polymerase chain reaction (PCR)-positive SARS-CoV-2 or coronavirus disease 2019 (COVID-19)