Assessment of Lipid Profile Treatment Practices and Lipid Levels in Post-Myocardial Infarction Patients: Results from a Tertiary Care Hospital of Pakistan

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pakistan Heart Journal Pub Date : 2023-11-16 DOI:10.47144/phj.v56isupplement_2.2682
Rubina Rauf, Muhammad Ismail Soomro, Muhammad Nauman Khan, Mukesh Kumar, N. Soomro, K. Kazmi
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Abstract

Objectives: Acute myocardial infarction (AMI) stands as a global leading cause of mortality. Following AMI, meticulous management of patients' lipid profiles for secondary prevention becomes paramount. We conducted this study to assess lipid profile practices and levels in post-AMI patients, which are crucial for secondary prevention. Methodology: In this cross-sectional study, we analyzed patients who had experienced their first AMI event in the past three years. We assessed fasting and non-fasting lipid profiles, reviewed statin therapy prescriptions, and examined patient compliance. The recommended dose was defined as rosuvastatin ≥20 mg or atorvastatin ≥40 mg, with target total cholesterol levels set at <160 mg/dL and target LDL (low-density lipoprotein) cholesterol at <55 mg/dL. Results: Among 195 patients, 71.3% were male, and the mean age was 57.1±10.2 years. The median duration since AMI was 36 [IQR: 10-48] months and 60% were diagnosed with STEMI (ST-segment elevation myocardial infarction). Only 13.8% of patients were advised to undergo lipid profile testing after AMI, 88.7% of patients were on the recommended statin therapy, and 91.8% of patients were compliant with statin therapy. Only 11.5% had LDL-cholesterol within the target range and 71.7% had total cholesterol within the target range. Hospital admission in the past 12 months was reported by 14.4%, and the re-admission rate was significantly higher among non-compliant patients (37.5% vs. 5.6%). Subsequent AMI event rate was also significantly higher among non-compliant patients (43.8% vs. 11.7%). Conclusion: Our study highlights that while most post-AMI patients receive the recommended minimum statin therapy, the inadequate practice of lipid assessment may compromise therapy optimization and raise the risk of subsequent events.
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评估心肌梗死后患者的血脂谱治疗方法和血脂水平:巴基斯坦一家三级医院的研究结果
目的:急性心肌梗死(AMI)是导致全球死亡的主要原因。急性心肌梗死后,对患者的血脂情况进行细致管理以进行二级预防变得至关重要。我们开展了这项研究,以评估急性心肌梗死后患者的血脂情况和水平,这对二级预防至关重要。 研究方法在这项横断面研究中,我们分析了在过去三年中经历过首次急性心肌梗死事件的患者。我们评估了空腹和非空腹血脂情况,查看了他汀类药物治疗处方,并检查了患者的依从性。推荐剂量定义为罗伐他汀≥20 毫克或阿托伐他汀≥40 毫克,目标总胆固醇水平设定为<160 毫克/分升,目标低密度脂蛋白胆固醇水平设定为<55 毫克/分升。 研究结果195名患者中,71.3%为男性,平均年龄为(57.1±10.2)岁。急性心肌梗死的中位持续时间为 36 [IQR: 10-48] 个月,60% 的患者被诊断为 STEMI(ST 段抬高型心肌梗死)。只有13.8%的患者在急性心肌梗死后被建议进行血脂检查,88.7%的患者接受了推荐的他汀类药物治疗,91.8%的患者遵从他汀类药物治疗。只有 11.5% 的患者低密度脂蛋白胆固醇在目标范围内,71.7% 的患者总胆固醇在目标范围内。据报告,14.4%的患者在过去12个月中曾入院治疗,而未遵医嘱患者的再次入院率明显更高(37.5% 对 5.6%)。未达标患者的后续急性心肌梗死事件发生率也明显更高(43.8% 对 11.7%)。 结论:我们的研究强调,虽然大多数急性心肌梗死后患者接受了推荐的最低限度他汀类药物治疗,但血脂评估实践不足可能会影响治疗的优化并增加后续事件的风险。
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来源期刊
Pakistan Heart Journal
Pakistan Heart Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
0.20
自引率
0.00%
发文量
64
审稿时长
6 weeks
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