P G Brouckaert, C Libert, B Everaerdt, N Takahashi, W Fiers
{"title":"A role for interleukin 1 in the in vivo actions of tumor necrosis factor.","authors":"P G Brouckaert, C Libert, B Everaerdt, N Takahashi, W Fiers","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We have observed a marked species specificity in the in vivo antitumor, shock-inducing and Interleukin-6 (IL-6)-inducing activities of human recombinant TNF (hrTNF) versus murine rTNF (mrTNF) in mouse models. We also have observed that this species specificity can be abolished when synergistic factors are co-administered. We now present data showing that the profiles of induced IL-6 and TNF after lethal and non-lethal doses of endotoxin are different. These results are discussed in the context of a model of dual signalling for the induction of the major post-endotoxin phenomena that takes into consideration the involvement of Interleukin-1 (IL-1) in the in vivo actions of TNF.</p>","PeriodicalId":18130,"journal":{"name":"Lymphokine research","volume":"8 3","pages":"269-74"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lymphokine research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We have observed a marked species specificity in the in vivo antitumor, shock-inducing and Interleukin-6 (IL-6)-inducing activities of human recombinant TNF (hrTNF) versus murine rTNF (mrTNF) in mouse models. We also have observed that this species specificity can be abolished when synergistic factors are co-administered. We now present data showing that the profiles of induced IL-6 and TNF after lethal and non-lethal doses of endotoxin are different. These results are discussed in the context of a model of dual signalling for the induction of the major post-endotoxin phenomena that takes into consideration the involvement of Interleukin-1 (IL-1) in the in vivo actions of TNF.