THE EFFECTIVENESS OF CEFTRIAXONE AND MEROPENEM IN THE TREATMENT OF ENTERIC FEVER IN CHILDREN- EXPERIENCE IN A TERTIARY CARE HOSPITAL IN PAKISTAN

Jan Muhammad Afridi, Sabahat Amir, Sana Pervez, Syed Kaleem Ur Rahman
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Abstract

Objectives: To determine the effectiveness of ceftriaxone and Meropenem in the treatment of Enteric Fever in the Pediatric Department of Khyber Teaching Hospital Peshawar. MATERIALS AND METHODS: This cross-sectional descriptive study was conducted at the Department of Child Health Khyber Teaching Hospital Peshawar Pakistan from June 2020 to June 2022. The sample size included 392 patients. Keeping in view 392 blood samples were taken and sent for blood culture. Both positive and negative cultures were incorporated in the study. The patients were started empirically on ceftriaxone and then in case of no response, the patients were shifted to Meropenem based on the sensitivity of the culture report. The response was defined as when the patient is afebrile for 72 hours after the treatment and the absence of complications like peritonitis, intestinal hemorrhage, and obtundation.  Data was analyzed using SPSS version 21.0.   RESULTS: In our study, out of 392 patients, 64% were males while 36% were females. Among blood cultures sent, 16.8% were positive and 83.2% were negative. Among the culture positive, 10.5% of patients were sensitive to Meropenem, 3.6% were sensitive to ceftriaxone and 2.8% were sensitive to other drugs. 60.7% of patients responded to Meropenem. Ceftriaxone-responsive patients were 11.7%, while 27.6% showed a response to other drugs. CONCLUSION: The efficacy of Meropenem was significantly high (in 2/3rd patients) while Ceftriaxone showed 11.73% efficacy. KEYWORDS: Enteric fever, ceftriaxone, Meropenem
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头孢曲松和美罗培南治疗儿童肠道热的有效性--巴基斯坦一家三级医院的经验
目的确定开伯尔教学医院白沙瓦儿科头孢曲松和美罗培南治疗肠热的有效性。材料与方法:这项横断面描述性研究于 2020 年 6 月至 2022 年 6 月在巴基斯坦白沙瓦开伯尔教学医院儿童健康部进行。样本量包括 392 名患者。共采集了 392 份血液样本并送去进行血液培养。阳性和阴性培养均纳入研究。患者开始使用头孢曲松进行经验性治疗,如果没有反应,则根据培养报告的敏感性转用美罗培南。治疗后 72 小时内患者无发热,且无腹膜炎、肠道出血和昏迷等并发症,即为应答。 数据使用 SPSS 21.0 版进行分析。 结果:在我们的研究中,392 名患者中有 64% 为男性,36% 为女性。在送检的血液培养物中,16.8%呈阳性,83.2%呈阴性。在培养阳性的患者中,10.5%对美罗培南敏感,3.6%对头孢曲松敏感,2.8%对其他药物敏感。60.7%的患者对美罗培南有反应。对头孢曲松有反应的患者占 11.7%,对其他药物有反应的患者占 27.6%。结论:美罗培南的疗效显著(2/3 的患者),而头孢曲松的疗效仅为 11.73%。关键词:肠热 头孢曲松 美罗培南
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