DETECTION OF ANTIBODIES TO SARS-COV-2 VIRUS IN PATIENTS WITH CORONARY HEART DISEASE AND SYSTEMIC RHEUMATIC DISEASES BEFORE THE ONSET OF THE COVID-19 PANDEMIC

Abstract

Seasonal coronaviruses may serve as an informative model for determining the duration of protection against reinfection during future waves of coronavirus disease. Data from the literature suggest that ELISA kits designed to detect antibodies to SARS-CoV-2 may also be sensitive to seasonal coronaviruses. The aim of our work was to perform a retrospective study to determine the presence of IgG and IgM to coronaviruses in Ukraine before the COVID-19 pandemic. The study was conducted on the serum of 321 patients with various cardiorheumatologic profiles who were treated in a hospital during 2013-2018. The obtained data indicate the possibility of cross-immunity among coronaviruses since antibodies to this virus were present in 3.3% of patients with acute myocardial infarction, 5.9% with systemic rheumatological diseases, and 27.3% with chronic coronary heart disease.