salivary calprotectin level in patients with oral lichen planus

Abstract

Objectives: assessment the concentration of calprotectin in the saliva of patients with oral lichen planus compared to healthy individuals and its relation with severity of the disease . Background: Calprotectin, a calcium-binding protein, is a key player in the pathogenesis of numerous inflammatory diseases, such as psoriasis and acne vulgaris. However, it has not been well studied in patients with oral lichen planus. Data Sources: By searching and reviewing Medline databases (Pub Med and Medscape) and looking for studies that examined the possible role of calprotectin in patients with oral lichen planus available till 2022. Study Selection: We independently reviewed all studies to determine if they met our criteria for inclusion. We included studies that met the following criteria;1.Written and published in English language. 2. Published in peer-reviewed journals.3.Explain how the level of salivary calprotectin may be linked to oral lichen planus and how it may affect severity of the disease . Data Extraction: Studies that did not meet our criteria were excluded from our review. We assessed the quality of the studies based on whether they had ethical approval, specified eligibility criteria, used appropriate controls, and provided adequate information and well-defined evaluation measures. We used a data collection form to independently extract data from each eligible study, focusing on the outcomes that were relevant to our study. Conclusions: Salivary calprotectin level is increased in patients with oral lichen planus compared to healthy control subjects