Student Competition (Technology Innovation) ID 1985155

IF 2.4 Q1 REHABILITATION Topics in Spinal Cord Injury Rehabilitation Pub Date : 2023-09-01 DOI:10.46292/sci23-1985155s
Amin Arefadib, Pouria Faridi, Soroush Mirkiani, Ashley Dalrymple, Vivian K. Mushahwar
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Abstract

ISMS entails implanting micro-electrodes into the spinal cord to produce synergistic activations of the legs. To date, ISMS has produced in-place stepping in cats with complete spinal cord injury (SCI) (Saigal et al, 2004), and long distances of over ground walking in anesthetized cats (Holinski et al, 2016). The goal of this project is to develop an intervention for restoring overground walking capacity for persons experiencing paralysis due to SCI, by investigating the potential of ISMS to enable long-distance overground walking in cats with chronic SCI. Experiments will be performed in eight adult cats with chronic complete SCI. The control strategy will include timed transitions between different phases of the step cycle, which will be modified using feedback from force plates and gyroscopes. The biomechanics of walking (speed of walking, stride length, left-right symmetry, inter-joint coordination) and muscle activation patterns will be recorded and analyzed. The stride-to-stride regularity of walking, amount of weight-bearing, and level of spasticity before, during, and after ISMS will be assessed. We expect that ISMS will produce long distances of walking (>500 m) in cats with SCI. The biomechanical features of walking will be similar to those in neurologically-intact cats. This project is a critical step towards demonstrating the viability of ISMS as a means for restoring functional walking after severe SCI. If successful, ISMS and the control strategies developed may in the future change the lives of many people living with SCI, giving them the capability to walk independently.
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学生竞赛(技术创新) ID 1985155
ISMS 需要将微电极植入脊髓,以产生腿部的协同激活。迄今为止,ISMS 已经在完全脊髓损伤(SCI)的猫身上产生了原地踏步的效果(Saigal 等人,2004 年),并在麻醉猫身上产生了长距离地面行走的效果(Holinski 等人,2016 年)。 本项目的目标是通过研究 ISMS 在慢性 SCI 猫中实现长距离地面行走的潜力,开发一种干预措施,以恢复因 SCI 而瘫痪者的地面行走能力。 实验将在 8 只患有慢性完全性 SCI 的成年猫身上进行。控制策略将包括步周期不同阶段之间的定时转换,并将利用力板和陀螺仪的反馈进行修改。将记录和分析行走的生物力学(行走速度、步幅、左右对称性、关节间协调性)和肌肉激活模式。在 ISMS 之前、期间和之后,还将对步行的步幅规律性、负重量和痉挛程度进行评估。 我们希望 ISMS 能让 SCI 猫实现长距离行走(>500 米)。行走的生物力学特征将与神经系统完好的猫相似。 该项目是证明 ISMS 作为严重 SCI 后恢复功能性行走的一种手段的可行性的关键一步。如果成功,ISMS 和所开发的控制策略将来可能会改变许多 SCI 患者的生活,使他们具备独立行走的能力。
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来源期刊
CiteScore
3.20
自引率
3.40%
发文量
33
期刊介绍: Now in our 22nd year as the leading interdisciplinary journal of SCI rehabilitation techniques and care. TSCIR is peer-reviewed, practical, and features one key topic per issue. Published topics include: mobility, sexuality, genitourinary, functional assessment, skin care, psychosocial, high tetraplegia, physical activity, pediatric, FES, sci/tbi, electronic medicine, orthotics, secondary conditions, research, aging, legal issues, women & sci, pain, environmental effects, life care planning
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