Changes in Optical Coherence Tomography Angiography after Suprachoroidal Triamcinolone Acetonide injection in Diabetic patients

Hamdy Elgazzar, Mohamed El-mohamdy, A. Abdelshafy, Amr Abd- Elkareem Abd-Elattif
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Abstract

Background: Diabetic macular edema (DME) is a leading cause for loss of central vision in diabetics with retinopathy. Treatment approaches for DME have shifted away from Laser therapy as the first line of therapy for DME. Aim and objectives: to investigate the changes in Optical coherence tomography angiography (OCT-A) after suprachoroidal injection of triamcinolone acetonide (SCTA) in patients with diabetic macular edema. Patients and Methods: This a prospective case series study that was conducted on twenty eyes with refractory diabetic macular edema who treated with single suprachoroidal injection of triamcinolone acetonide. All patients underwent history taking, ocular examination and optical coherence tomography angiography (OCT-Angiography). Results: there was no statistically significant difference between the studied groups as regard (Relation between baseline, third month and sixth month LogMAR BCVA), (Relation between baseline, third month and sixth month CFT (Central foveal thickness)), (Relation between baseline, third month, sixth month SVD (superficial vessel density) and sixth month DVD (Deep vessel density)), (Relation between baseline, third month and sixth month FAZ (Foveal avascular zone) in mm) and (Correlation between BCVA at six month and (CFT, SVD, DVD, FAZ) at six months). Conclusion: our findings suggest that SCTA may be an effective treatment option for diabetic macular edema, improving visual outcomes and reducing retinal thickness.
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糖尿病患者脉络膜上注射曲安奈德后光学相干断层扫描血管造影的变化
背景:糖尿病黄斑水肿(DME)是糖尿病视网膜病变患者丧失中心视力的主要原因。糖尿病黄斑水肿的治疗方法已从激光治疗转变为第一线治疗。目的和目标:研究糖尿病黄斑水肿患者脉络膜上注射曲安奈德(SCTA)后光学相干断层血管造影(OCT-A)的变化。患者和方法:这是一项前瞻性病例系列研究,研究对象是20名难治性糖尿病黄斑水肿患者,他们都接受了单次脉络膜上注射曲安奈德的治疗。所有患者均接受了病史采集、眼部检查和光学相干断层血管成像(OCT-Angiography)检查。结果在基线、第三个月和第六个月的 LogMAR BCVA 之间的关系)、(基线、第三个月和第六个月的 CFT(中央眼窝厚度)之间的关系)、(基线、第三个月和第六个月的 SVD(中央眼窝厚度)之间的关系)方面,研究组之间没有明显的统计学差异、基线、第三个月和第六个月的 SVD(浅层血管密度)与第六个月的 DVD(深层血管密度)之间的关系)、(基线、第三个月和第六个月的 FAZ(眼窝无血管区)(单位:毫米)之间的关系)以及(六个月时的 BCVA 与六个月时的(CFT、SVD、DVD、FAZ)之间的相关性)。结论:我们的研究结果表明,SCTA 可能是治疗糖尿病性黄斑水肿的一种有效方法,它能改善视觉效果并降低视网膜厚度。
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