S. Ndlovu, T. M. Esterhuizen, R. Uys, MB ChB, M. Kruger, FC Paed
{"title":"Trends in childhood cancers at Tygerberg Hospital from 1994 to 2014","authors":"S. Ndlovu, T. M. Esterhuizen, R. Uys, MB ChB, M. Kruger, FC Paed","doi":"10.7196/sajch.2023.v17i2.1944","DOIUrl":null,"url":null,"abstract":"Background. There is a paucity of data regarding childhood cancer incidence in low- and middle-income countries owing to a lack ofdisease-specific, hospital- and population-based registries.Objective. To describe the disease profile and outcome of children with cancer, treated at a single institution in South Africa between1994 and 2014.Methods. Data collected included demographic data (age at diagnosis, sex, stage or risk group, race) and 5-year overall survival (OS) of children aged ≤15 years diagnosed with cancer. Time to event and factors associated with 5-year outcomes were analysed, using Kaplan-Meier curves and Cox regression analysis.Results. The most common malignancies were leukaemia (27.7%), brain tumours (18.4%), lymphomas (14.1%), nephroblastoma (8.0%)and soft-tissue sarcomas (7.4%) for 935 patient records. Limited-disease solid tumours and standard-risk haematological malignancieshad good OS rates of 77.7% and 85.9%, respectively, although OS for the whole group was 60.2%. Nephroblastoma (89.3%), retinoblastoma (86.7%), Hodgkin’s lymphoma (89.7%) and Burkitt lymphoma (75.5%) had the best OS. Type of cancer (p<0.01), solid-tumour stage (p<0.001) and risk classification for haematological malignancies (p<0.001) were significantly associated with mortality.Conclusions. Underlying cancer diagnosis, stage and risk group remained significant factors influencing survival with good OS for limited disease in solid tumours and standard-risk haematological malignancies, which was comparable with survival rates in high-income countries.","PeriodicalId":44732,"journal":{"name":"South African Journal of Child Health","volume":"67 1","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Journal of Child Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7196/sajch.2023.v17i2.1944","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background. There is a paucity of data regarding childhood cancer incidence in low- and middle-income countries owing to a lack ofdisease-specific, hospital- and population-based registries.Objective. To describe the disease profile and outcome of children with cancer, treated at a single institution in South Africa between1994 and 2014.Methods. Data collected included demographic data (age at diagnosis, sex, stage or risk group, race) and 5-year overall survival (OS) of children aged ≤15 years diagnosed with cancer. Time to event and factors associated with 5-year outcomes were analysed, using Kaplan-Meier curves and Cox regression analysis.Results. The most common malignancies were leukaemia (27.7%), brain tumours (18.4%), lymphomas (14.1%), nephroblastoma (8.0%)and soft-tissue sarcomas (7.4%) for 935 patient records. Limited-disease solid tumours and standard-risk haematological malignancieshad good OS rates of 77.7% and 85.9%, respectively, although OS for the whole group was 60.2%. Nephroblastoma (89.3%), retinoblastoma (86.7%), Hodgkin’s lymphoma (89.7%) and Burkitt lymphoma (75.5%) had the best OS. Type of cancer (p<0.01), solid-tumour stage (p<0.001) and risk classification for haematological malignancies (p<0.001) were significantly associated with mortality.Conclusions. Underlying cancer diagnosis, stage and risk group remained significant factors influencing survival with good OS for limited disease in solid tumours and standard-risk haematological malignancies, which was comparable with survival rates in high-income countries.