Serum Plasma Thiol Evaluation in Chronic Telogen Effluvium Patients

Abstract

Background: Oxidative stress has been linked to chronic telogen effluvium (CTE). In a physiological sense, free radicals are eliminated by thiols, which are powerful and stable antioxidants. When oxidative stress is present, thiols are the body's go-to antioxidant. The purpose of this study is to compare serum total thiol, thiol-disulphide, and disulphide levels in female CTE patients to those of healthy controls. Topics and Approaches: Sixty people with CTE and twenty age-and sex-matched healthy volunteers served as the case and control groups, respectively, in this case-control research. From May 2020 to December 2021, they were scouted from the outpatient clinic of the Dermatology, Venereology, and Andrology Department at Benha University Hospitals. Results: There was no statistically significant difference in age or body mass index between the patients and the controls. In patients, total thiol levels were considerably lower than in controls. Patients had considerably lower levels of thiol-disulphide compared to healthy controls. Patients had considerably lower levels of disulphide compared to controls. The pathophysiology of TE is intimately linked to oxidative stress, we conclude. The development and prevention of oxidative stress are both influenced by the thiol-disulfide equilibrium. TE upsets this delicate equilibrium.