Cytotoxic and anti-metastatic action mediates the anti-proliferative activity of Rhazya stricta Decne inducing apoptotic cell death in human cancer cells: Implication in chemopreventive mechanism

IF 0.7 4区 农林科学 Q3 AGRONOMY Emirates Journal of Food and Agriculture Pub Date : 2023-06-08 DOI:10.9755/ejfa.2023.3132
M. Ullah, Faisel M. Abuduhier, Showket H. Bhat, Aamir Ahmad, Mohammad Rehan Ajmal, Syed Khalid Mustafa
{"title":"Cytotoxic and anti-metastatic action mediates the anti-proliferative activity of Rhazya stricta Decne inducing apoptotic cell death in human cancer cells: Implication in chemopreventive mechanism","authors":"M. Ullah, Faisel M. Abuduhier, Showket H. Bhat, Aamir Ahmad, Mohammad Rehan Ajmal, Syed Khalid Mustafa","doi":"10.9755/ejfa.2023.3132","DOIUrl":null,"url":null,"abstract":"Cancer is associated with a high rate of pre-mature mortality worldwide and serves as a significant impediment to extended life expectancy, leading to undesirable long-term effects on the quality of life of the patients. Bioactive chemical products derived from natural sources have an important place in the well-being of the human population since ancient times. Compounds derived from natural sources have dominated the drug discovery programs in the last five decades and comprise a substantial proportion of current-day pharmaceutical agents. Rhazya stricta, an evergreen shrub, it belongs to family Apocynaceae of order Gentianales, and the Rhazya stricta is known to have certain medicinal properties, as the Middle East and South Asian traditional medicine employed this plant as a cure for different diseases. Herein, the hydro-methanolic extract of Rhazya stricta Decne has been studied for its effect on spectrum of cancer cells, including LNCaP, C4-2B, PC-3 prostate cancer cells, MDA-MB-231, MCF-7, SKBR3 breast cancer cells, A-549 lung cancer cells and BxPC-3, MiaPaCa-2 pancreatic cancer. Hydro-methanolic extract of Rhazya stricta Decne in a dose-dependent manner, showed progressive inhibition of cell growth by induction of cell death in the treated human cancer cells. The IC value range for different breast cancer cell lines was 142-178 µg/ml; for prostate cancer cell lines, it was 90-148 µg/ml; for pancreatic cancer cell lines 116-166 µg/ml and for the lung cancer cells, it was reported to be 180 µg/ml. The anti-metastatic potential of extract was indicated by the notable reduction in invasiveness and cell migration. Moreover, the structurally diverse phytochemical rich extract, also downregulates the signaling of NF-kB and the NF-kB downstream target cytokine VEGF, providing an insight into the anticancer action mechanism.Keywords: Cell biology; Cancer chemoprevention; Anticancer drugs; Cell signaling; Natural compounds","PeriodicalId":11648,"journal":{"name":"Emirates Journal of Food and Agriculture","volume":"75 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emirates Journal of Food and Agriculture","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.9755/ejfa.2023.3132","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"AGRONOMY","Score":null,"Total":0}
引用次数: 0

Abstract

Cancer is associated with a high rate of pre-mature mortality worldwide and serves as a significant impediment to extended life expectancy, leading to undesirable long-term effects on the quality of life of the patients. Bioactive chemical products derived from natural sources have an important place in the well-being of the human population since ancient times. Compounds derived from natural sources have dominated the drug discovery programs in the last five decades and comprise a substantial proportion of current-day pharmaceutical agents. Rhazya stricta, an evergreen shrub, it belongs to family Apocynaceae of order Gentianales, and the Rhazya stricta is known to have certain medicinal properties, as the Middle East and South Asian traditional medicine employed this plant as a cure for different diseases. Herein, the hydro-methanolic extract of Rhazya stricta Decne has been studied for its effect on spectrum of cancer cells, including LNCaP, C4-2B, PC-3 prostate cancer cells, MDA-MB-231, MCF-7, SKBR3 breast cancer cells, A-549 lung cancer cells and BxPC-3, MiaPaCa-2 pancreatic cancer. Hydro-methanolic extract of Rhazya stricta Decne in a dose-dependent manner, showed progressive inhibition of cell growth by induction of cell death in the treated human cancer cells. The IC value range for different breast cancer cell lines was 142-178 µg/ml; for prostate cancer cell lines, it was 90-148 µg/ml; for pancreatic cancer cell lines 116-166 µg/ml and for the lung cancer cells, it was reported to be 180 µg/ml. The anti-metastatic potential of extract was indicated by the notable reduction in invasiveness and cell migration. Moreover, the structurally diverse phytochemical rich extract, also downregulates the signaling of NF-kB and the NF-kB downstream target cytokine VEGF, providing an insight into the anticancer action mechanism.Keywords: Cell biology; Cancer chemoprevention; Anticancer drugs; Cell signaling; Natural compounds
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
细胞毒性和抗转移作用介导了 Rhazya stricta Decne 诱导人类癌细胞凋亡的抗增殖活性:化学预防机制的含义
在全球范围内,癌症导致的过早死亡率很高,是延长预期寿命的一大障碍,并对患者的生活质量造成长期不良影响。自古以来,从天然资源中提取的生物活性化学产品在人类福祉中占有重要地位。在过去的五十年里,从天然资源中提取的化合物在药物发现项目中占据了主导地位,并在当今的药物制剂中占有相当大的比例。Rhazya stricta 是一种常绿灌木,属于龙胆科龙胆属,众所周知,Rhazya stricta 具有一定的药用价值,中东和南亚的传统医学利用这种植物治疗不同的疾病。在此,我们研究了狭叶龙胆的水甲醇提取物对多种癌细胞的影响,包括 LNCaP、C4-2B、PC-3 前列腺癌细胞,MDA-MB-231、MCF-7、SKBR3 乳腺癌细胞,A-549 肺癌细胞和 BxPC-3、MiaPaCa-2 胰腺癌细胞。Rhazya stricta Decne 的水甲醇提取物以剂量依赖的方式,通过诱导细胞死亡来逐步抑制受处理人类癌细胞的生长。不同乳腺癌细胞株的 IC 值范围为 142-178 微克/毫升;前列腺癌细胞株的 IC 值范围为 90-148 微克/毫升;胰腺癌细胞株的 IC 值范围为 116-166 微克/毫升;肺癌细胞的 IC 值范围为 180 微克/毫升。萃取物的抗转移潜力表现在显著降低侵袭性和细胞迁移。此外,富含多种植物化学物质的提取物还能下调NF-kB和NF-kB下游靶细胞因子VEGF的信号转导,从而揭示其抗癌作用机制:细胞生物学 癌症化学预防 抗癌药物 细胞信号传导 天然化合物
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Emirates Journal of Food and Agriculture
Emirates Journal of Food and Agriculture AGRONOMYFOOD SCIENCE & TECHNOLOGY&nb-FOOD SCIENCE & TECHNOLOGY
CiteScore
1.80
自引率
0.00%
发文量
18
期刊介绍: The "Emirates Journal of Food and Agriculture [EJFA]" is a unique, peer-reviewed Journal of Food and Agriculture publishing basic and applied research articles in the field of agricultural and food sciences by the College of Food and Agriculture, United Arab Emirates University, United Arab Emirates.
期刊最新文献
Physicochemical and sensory characteristics of bioplastics from phosphate butyrylated arenga starches Assessing Technical Efficiency in Malaysian Pineapple Farms: A Stochastic Frontier Analysis Approach Sweetener Food Additives: A Synoptical Overview on Their Chemical Properties, Applications in Food Products and Side Effects Marine Algal Extract as a Biostimulant to Improve Tolerance to Salinity in Lettuce Plants Influence of phenolic compounds and flavonoids on the colour and antioxidant activity of Melipona beecheii honey from deciduous forest of Yucatan, Mexico
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1