Clinical outcome and component-specific antibody levels in egg allergic children after lightened oral immunotherapy.

IF 2.5 4区医学 Q3 ALLERGY Allergologia et immunopathologia Pub Date : 2024-01-01 DOI:10.15586/aei.v52i1.805

Anna Koffert, Jussi Liippo, Eliisa Löyttyniemi, Johannes Savolainen

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Abstract

Objective: To evaluate the clinical outcome of lightened version of egg oral immunotherapy (OIT) and to analyze egg allergen component-specific antibody levels during short up-dosing with egg white powder and maintenance by egg in daily diet.

Patients and methods: Eighteen egg-allergic children received egg powder with short up--dosing and they maintained tolerance using egg in daily diet. Seventeen egg-allergic children served as a control group. Component-resolved analysis of serum immunoglobulin E (IgE), IgA1, IgA2, and IgG4 levels were determined at inclusion, after up-dosing and after 1 year of immunotherapy. Skin-prick tests were performed at inclusion and after 1 year of therapy.

Results: All 18 patients in the egg OIT group were successfully desensitized. Desensitization was achieved on average in 4.5 months. In the control group, only two children tolerated egg in oral food challenge after 1 year. Of the measured immune markers, smaller wheal diameters in skin-prick testing, reduction in component-specific IgE levels, and increase in component-specific IgA1, IgA2, and IgG4 levels were associated with desensitization.

Conclusion: A lightened egg OIT is effective and safe in children with egg allergy. Increase in all egg component-specific IgA1, IgA2 and IgG4 levels and decrease in all egg component--specific IgE levels were observed after 12 months of OIT.

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淡化口服免疫疗法后鸡蛋过敏儿童的临床疗效和特异性抗体水平。

目的评估轻型鸡蛋口服免疫疗法（OIT）的临床疗效，并分析使用蛋白粉短期加量治疗和在日常饮食中添加鸡蛋维持治疗期间的鸡蛋过敏原特异性抗体水平：18名对鸡蛋过敏的儿童接受了鸡蛋粉短期增量治疗，并通过在日常饮食中添加鸡蛋来维持耐受性。17名鸡蛋过敏儿童作为对照组。在入组时、加量给药后和免疫治疗一年后，分别测定了血清免疫球蛋白E（IgE）、IgA1、IgA2和IgG4水平的成分分辨分析。在入组时和治疗一年后进行了皮肤点刺试验：鸡蛋 OIT 组的所有 18 名患者均成功脱敏。脱敏平均需要 4.5 个月。在对照组中，只有两名患儿在 1 年后能在口服食物挑战中耐受鸡蛋。在测量的免疫标记物中，皮肤点刺试验中较小的乳清直径、成分特异性 IgE 水平的降低以及成分特异性 IgA1、IgA2 和 IgG4 水平的升高与脱敏有关：结论：淡化鸡蛋 OIT 对鸡蛋过敏儿童有效且安全。经过 12 个月的 OIT 治疗，观察到所有鸡蛋成分特异性 IgA1、IgA2 和 IgG4 水平均有所上升，所有鸡蛋成分特异性 IgE 水平均有所下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.